S100vp S100 calcium-binding protein, ventral prostate [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: S100vpprovided by RGD
Official Full Name: S100 calcium-binding protein, ventral prostateprovided by RGD
Primary source: RGD:631357
See related: EnsemblRapid:ENSRNOG00000028310 AllianceGenome:RGD:631357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: S100RVP
Summary: Enables calcium ion binding activity. Involved in intracellular calcium ion homeostasis and response to testosterone. Predicted to be active in sarcoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1.2) See more
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Genomic context

Location:: 2q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (179094066..179097417, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (176748273..176751624, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (190628525..190631821)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of this study argue for a role of S100RVP in calcium homeostasis in the prostate
Title: Regulation of calcium homeostasis by S100RVP, an androgen-regulated S100 protein in the rat ventral prostate.

Submit: New GeneRIF Correction

General gene information

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Markers

BI281560 (e-PCR)
- UniSTS:249504

BI278666 (e-PCR)
- UniSTS:244441

BI278703 (e-PCR)
- UniSTS:244448

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S100 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: S100 calcium-binding protein, ventral prostate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176076.4 → NP_788265.1 S100 calcium-binding protein, ventral prostate

See identical proteins and their annotated locations for NP_788265.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6KMS0, F7FGS5, Q80VT8

Related

ENSRNOP00000023564.2, ENSRNOT00000023564.5

Conserved Domains (1) summary

cl08302
Location:6 → 85

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...