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    Timd2 T-cell immunoglobulin and mucin domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Timd2provided by RGD
    Official Full Name
    T-cell immunoglobulin and mucin domain containing 2provided by RGD
    Primary source
    RGD:1359571
    See related
    EnsemblRapid:ENSRNOG00000021345 AllianceGenome:RGD:1359571
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tim2
    Summary
    Predicted to enable ferritin receptor activity; phosphatidylserine binding activity; and virus receptor activity. Predicted to be involved in phagocytosis, engulfment and positive regulation of mast cell activation. Predicted to act upstream of or within iron ion transport. Predicted to be located in plasma membrane. Predicted to be active in cell surface. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 499.5), Kidney (RPKM 42.7) and 1 other tissue See more
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    Genomic context

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    See Timd2 in Genome Data Viewer
    Location:
    10q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (31561563..31602515, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (31060308..31101262, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (31755473..31796423, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene hepatitis A virus cellular receptor 1 like 2 Neighboring gene developmental pluripotency associated 1 Neighboring gene lysine methyltransferase 5A, pseudogene 2 Neighboring gene hepatitis A virus cellular receptor 1 Neighboring gene surfeit 6, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. Han J, et al. PLoS One, 2011. PMID 21886823, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108812

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ferritin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables virus receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within iron ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagocytosis, engulfment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mast cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-cell immunoglobulin and mucin domain-containing protein 2
    Names
    T-cell immunoglobulin mucin receptor 2
    T-cell membrane protein 2
    TIM-2
    TIMD-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013855.1 → NP_001013877.1  T-cell immunoglobulin and mucin domain-containing protein 2 precursor

      See identical proteins and their annotated locations for NP_001013877.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089832
      UniProtKB/Swiss-Prot
      Q5FVR0
      Related
      ENSRNOP00000056223.2, ENSRNOT00000059468.5
      Conserved Domains (2) summary
      smart00410
      Location:21 → 124
      IG_like; Immunoglobulin like
      pfam07686
      Location:23 → 107
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      31561563..31602515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246168.4 → XP_006246230.1  T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006246230.1

      UniProtKB/Swiss-Prot
      Q5FVR0
      Conserved Domains (2) summary
      smart00410
      Location:21 → 124
      IG_like; Immunoglobulin like
      pfam07686
      Location:23 → 107
      V-set; Immunoglobulin V-set domain

    2. XM_008767669.4 → XP_008765891.1  T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008765891.1

      UniProtKB/Swiss-Prot
      Q5FVR0
      Conserved Domains (2) summary
      smart00410
      Location:21 → 124
      IG_like; Immunoglobulin like
      pfam07686
      Location:23 → 107
      V-set; Immunoglobulin V-set domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVR0.1 GenPept UniProtKB/Swiss-Prot:Q5FVR0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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