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    Paip1 poly(A) binding protein interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365684, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Paip1provided by RGD
    Official Full Name
    poly(A) binding protein interacting protein 1provided by RGD
    Primary source
    RGD:1305668
    See related
    EnsemblRapid:ENSRNOG00000058580 AllianceGenome:RGD:1305668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable translation activator activity. Predicted to be involved in CRD-mediated mRNA stabilization; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of cytoplasmic translation. Predicted to act upstream of with a positive effect on viral translation. Predicted to be located in cytosol. Predicted to be part of mCRD-mediated mRNA stability complex. Predicted to be active in cytoplasm. Orthologous to human PAIP1 (poly(A) binding protein interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 243.2), Kidney (RPKM 213.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Paip1 in Genome Data Viewer
    Location:
    2q15
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (53255916..53282965)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (51523190..51550241)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (52300921..52328212)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene nicotinamide nucleotide transhydrogenase Neighboring gene small nucleolar RNA SNORD36 Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene similar to human chromosome 5 open reading frame 34 Neighboring gene transmembrane protein 267

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Craig AW, et al. Nature, 1998 Apr 2. PMID 9548260
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CRD-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_positive_effect viral translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mCRD-mediated mRNA stability complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polyadenylate-binding protein-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108937.2 → NP_001102407.1  polyadenylate-binding protein-interacting protein 1 isoform b

      See identical proteins and their annotated locations for NP_001102407.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I5V5, B2RZ22
      Related
      ENSRNOP00000069142.3, ENSRNOT00000081157.3
      Conserved Domains (1) summary
      pfam02854
      Location:48 → 264
      MIF4G; MIF4G domain

    2. NM_001399758.1 → NP_001386687.1  polyadenylate-binding protein-interacting protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      B2RZ22

    3. NM_001399759.1 → NP_001386688.1  polyadenylate-binding protein-interacting protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I5V5, B2RZ22

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      53255916..53282965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760778.4 → XP_008759000.1  polyadenylate-binding protein-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JVP5
      Related
      ENSRNOP00000069568.2, ENSRNOT00000091387.3
      Conserved Domains (2) summary
      PHA03160
      Location:36 → 116
      PHA03160; hypothetical protein; Provisional
      pfam02854
      Location:161 → 377
      MIF4G; MIF4G domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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