Zdhhc15 zinc finger DHHC-type palmitoyltransferase 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zdhhc15provided by RGD
Official Full Name: zinc finger DHHC-type palmitoyltransferase 15provided by RGD
Primary source: RGD:1562075
See related: EnsemblRapid:ENSRNOG00000002751 AllianceGenome:RGD:1562075
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Involved in positive regulation of dendrite development; protein localization to postsynapse; and regulation of dendritic spine morphogenesis. Located in Golgi membrane and postsynapse. Orthologous to human ZDHHC15 (zinc finger DHHC-type palmitoyltransferase 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 64.8), Kidney (RPKM 42.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (73633977..73767451, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (69568086..69701756, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (75433957..75566531, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

knocking down zDHHC15 in primary rat hippocampal cultures reduces dendritic outgrowth and arborization, as well as spine maturation.
Title: Regulation of dendrite morphology and excitatory synapse formation by zDHHC15.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-palmitoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-cysteine S-stearoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-L-cysteine S-palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-L-cysteine S-palmitoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle maturation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic vesicle maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC15

Names: DHHC-15; acyltransferase ZDHHC15; membrane-associated DHHC15 zinc finger protein; zinc finger DHHC domain-containing protein 15; zinc finger, DHHC domain containing 15; zinc finger, DHHC-type containing 15

NP_001034190.1

EC 2.3.1.225

XP_006257207.1

EC 2.3.1.225

XP_038955668.1

EC 2.3.1.225

XP_063136095.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039101.1 → NP_001034190.1 palmitoyltransferase ZDHHC15

See identical proteins and their annotated locations for NP_001034190.1

Status: PROVISIONAL

Source sequence(s)

AY886531

UniProtKB/Swiss-Prot

Q2TGJ4

Related

ENSRNOP00000003714.5, ENSRNOT00000003714.7

Conserved Domains (1) summary

cl19890
Location:125 → 308

zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

73633977..73767451 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257145.5 → XP_006257207.1 palmitoyltransferase ZDHHC15 isoform X1

See identical proteins and their annotated locations for XP_006257207.1

UniProtKB/Swiss-Prot

Q2TGJ4

Related

ENSRNOP00000102726.1, ENSRNOT00000150380.1

Conserved Domains (1) summary

cl19890
Location:125 → 308

zf-DHHC; DHHC palmitoyltransferase
XM_039099740.2 → XP_038955668.1 palmitoyltransferase ZDHHC15 isoform X2

UniProtKB/TrEMBL

A6IV19

Conserved Domains (1) summary

cl19890
Location:17 → 200

DHHC; DHHC palmitoyltransferase
XM_063280025.1 → XP_063136095.1 palmitoyltransferase ZDHHC15 isoform X2

UniProtKB/TrEMBL

A6IV19