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    Acbd4 acyl-CoA binding domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303577, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acbd4provided by RGD
    Official Full Name
    acyl-CoA binding domain containing 4provided by RGD
    Primary source
    RGD:1308404
    See related
    EnsemblRapid:ENSRNOG00000003108 AllianceGenome:RGD:1308404
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human ACBD4 (acyl-CoA binding domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 92.7), Liver (RPKM 43.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acbd4 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88548146..88558588)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88048058..88062612)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91186131..91200081)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene dephospho-CoA kinase domain containing Neighboring gene N-myristoyltransferase 1 Neighboring gene phospholipase C, delta 3 Neighboring gene HEXIM P-TEFb complex subunit 1 Neighboring gene HEXIM P-TEFb complex subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA-binding domain-containing protein 4
    Names
    acyl-Coenzyme A binding domain containing 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012013.1 → NP_001012013.1  acyl-CoA-binding domain-containing protein 4

      See identical proteins and their annotated locations for NP_001012013.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076387
      UniProtKB/Swiss-Prot
      Q6DGF9
      UniProtKB/TrEMBL
      A0A8I6A6R0
      Conserved Domains (1) summary
      pfam00887
      Location:11 → 91
      ACBP; Acyl CoA binding protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      88548146..88558588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768287.4 → XP_008766509.1  acyl-CoA-binding domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6R0
      Conserved Domains (1) summary
      cd00435
      Location:11 → 95
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    2. XM_006247508.5 → XP_006247570.1  acyl-CoA-binding domain-containing protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006247570.1

      UniProtKB/TrEMBL
      A0A8I6A6R0, A6HJP7
      Related
      ENSRNOP00000004163.6, ENSRNOT00000004163.6
      Conserved Domains (1) summary
      cd00435
      Location:11 → 95
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    3. XM_006247510.5 → XP_006247572.1  acyl-CoA-binding domain-containing protein 4 isoform X4

      See identical proteins and their annotated locations for XP_006247572.1

      UniProtKB/Swiss-Prot
      Q6DGF9
      UniProtKB/TrEMBL
      A0A8I6A6R0
      Conserved Domains (1) summary
      pfam00887
      Location:11 → 91
      ACBP; Acyl CoA binding protein

    4. XM_039086115.2 → XP_038942043.1  acyl-CoA-binding domain-containing protein 4 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A6R0, A0A8L2UHQ5
      Conserved Domains (1) summary
      pfam00887
      Location:11 → 91
      ACBP; Acyl CoA binding protein

    5. XM_063269166.1 → XP_063125236.1  acyl-CoA-binding domain-containing protein 4 isoform X4

      UniProtKB/Swiss-Prot
      Q6DGF9
      UniProtKB/TrEMBL
      A0A8I6A6R0

    6. XM_063269167.1 → XP_063125237.1  acyl-CoA-binding domain-containing protein 4 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A6R0, A0A8L2UHQ5

    7. XM_063269163.1 → XP_063125233.1  acyl-CoA-binding domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6R0

    8. XM_063269164.1 → XP_063125234.1  acyl-CoA-binding domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6R0, A6HJP7

    9. XM_063269169.1 → XP_063125239.1  acyl-CoA-binding domain-containing protein 4 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A6R0

    10. XM_063269168.1 → XP_063125238.1  acyl-CoA-binding domain-containing protein 4 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A6R0
      Related
      ENSRNOP00000088718.2, ENSRNOT00000118852.2

    11. XM_063269170.1 → XP_063125240.1  acyl-CoA-binding domain-containing protein 4 isoform X9

      UniProtKB/TrEMBL
      A6HJQ0
      Related
      ENSRNOP00000111179.1, ENSRNOT00000136036.1

    12. XM_006247509.5 → XP_006247571.1  acyl-CoA-binding domain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A6R0
      Conserved Domains (1) summary
      pfam00887
      Location:11 → 91
      ACBP; Acyl CoA binding protein

    13. XM_006247512.5 → XP_006247574.1  acyl-CoA-binding domain-containing protein 4 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A6R0
      Conserved Domains (1) summary
      pfam00887
      Location:11 → 91
      ACBP; Acyl CoA binding protein

    14. XM_063269171.1 → XP_063125241.1  acyl-CoA-binding domain-containing protein 4 isoform X9

      UniProtKB/TrEMBL
      A6HJQ0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DGF9.1 GenPept UniProtKB/Swiss-Prot:Q6DGF9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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