U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rufy2 RUN and FYVE domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690777, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Symbol
    Rufy2provided by RGD
    Full Name
    RUN and FYVE domain containing 2provided by RGD
    Primary source
    RGD:1592188
    See related
    EnsemblRapid:ENSRNOG00000065563 AllianceGenome:RGD:1592188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to be active in cytoplasm. Orthologous to human RUFY2 (RUN and FYVE domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 94.2), Kidney (RPKM 66.6) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rufy2 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (25566950..25657937, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (25626958..25658157, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (27219729..27250006, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29, pseudogene 22 Neighboring gene phenazine biosynthesis-like protein domain containing 1 Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein H3 Neighboring gene solute carrier family 25 member 16 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene small nucleolar RNA SNORA70

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking. Yang J, et al. J Biol Chem, 2002 Aug 16. PMID 11877430
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    RUN and FYVE domain-containing protein 2
    Names
    RUN and FYVE domain-containing protein 2-like

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168586.1 → NP_001162058.1  RUN and FYVE domain-containing protein 2

      See identical proteins and their annotated locations for NP_001162058.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6JL02
      Related
      ENSRNOP00000035701.7, ENSRNOT00000037409.8
      Conserved Domains (3) summary
      COG1196
      Location:181 → 536
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl28890
      Location:534 → 603
      FYVE_like_SF; FYVE domain like superfamily
      pfam02759
      Location:45 → 166
      RUN; RUN domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      25566950..25657937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279538.1 → XP_063135608.1  RUN and FYVE domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6JL02

    2. XM_039099096.2 → XP_038955024.1  RUN and FYVE domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6JL02
      Conserved Domains (3) summary
      COG1196
      Location:312 → 667
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl28890
      Location:665 → 734
      FYVE_like_SF; FYVE domain like superfamily
      pfam02759
      Location:176 → 297
      RUN; RUN domain

    3. XM_063279536.1 → XP_063135606.1  RUN and FYVE domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6JL02

    4. XM_063279537.1 → XP_063135607.1  RUN and FYVE domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6JL02

    5. XM_063279540.1 → XP_063135610.1  RUN and FYVE domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A6JL02

    6. XM_063279542.1 → XP_063135612.1  RUN and FYVE domain-containing protein 2 isoform X4

    7. XM_063279541.1 → XP_063135611.1  RUN and FYVE domain-containing protein 2 isoform X4

    8. XM_063279539.1 → XP_063135609.1  RUN and FYVE domain-containing protein 2 isoform X2

      Related
      ENSRNOP00000073001.3, ENSRNOT00000084720.3

    9. XM_063279543.1 → XP_063135613.1  RUN and FYVE domain-containing protein 2 isoform X5

    10. XM_063279544.1 → XP_063135614.1  RUN and FYVE domain-containing protein 2 isoform X8

    11. XM_039099101.2 → XP_038955029.1  RUN and FYVE domain-containing protein 2 isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:312 → 545
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam02759
      Location:176 → 297
      RUN; RUN domain

    12. XM_039099102.2 → XP_038955030.1  RUN and FYVE domain-containing protein 2 isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:329 → 533
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam02759
      Location:176 → 297
      RUN; RUN domain

    13. XM_063279545.1 → XP_063135615.1  RUN and FYVE domain-containing protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6GHY0

    14. XM_063279547.1 → XP_063135617.1  RUN and FYVE domain-containing protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A8I6GHY0

    15. XM_063279548.1 → XP_063135618.1  RUN and FYVE domain-containing protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A8I6GHY0

    16. XM_063279546.1 → XP_063135616.1  RUN and FYVE domain-containing protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZTG8, A0A8I6GHY0
      Related
      ENSRNOP00000081901.1, ENSRNOT00000112698.2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.