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    Tprkb Tp53rk binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297411, updated on 9-Dec-2024

    Summary

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    Symbol
    Tprkbprovided by RGD
    Full Name
    Tp53rk binding proteinprovided by RGD
    Primary source
    RGD:1309786
    See related
    EnsemblRapid:ENSRNOG00000050645 AllianceGenome:RGD:1309786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cgi-121; RGD1309786
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 5. Orthologous to human TPRKB (TP53RK binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 167.9), Adrenal (RPKM 84.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tprkb in Genome Data Viewer
    Location:
    4q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (119900374..119915374)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (118342910..118357908)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (117589527..117604481)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 4 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 1 Neighboring gene N-acetyltransferase 8B Neighboring gene dual specificity phosphatase 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein. Miyoshi A, et al. Biochem Biophys Res Commun, 2003 Apr 4. PMID 12659830
    2. Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7. Wan LC, et al. Nucleic Acids Res, 2017 Jan 25. PMID 27903914, Free PMC Article
    3. Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Braun DA, et al. Nat Genet, 2017 Oct. PMID 28805828, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EKC/KEOPS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of EKC/KEOPS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    EKC/KEOPS complex subunit Tprkb
    Names
    PRPK-binding protein
    Prpk (p53-related protein kinase)-binding protein
    TP53RK-binding protein
    TP53RK-binding protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013926.3 → NP_001013948.2  EKC/KEOPS complex subunit Tprkb

      See identical proteins and their annotated locations for NP_001013948.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q5PQR8
      UniProtKB/TrEMBL
      A6IAU0, A6IAU1, G3V805
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      119900374..119915374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107360.2 → XP_038963288.1  EKC/KEOPS complex subunit Tprkb isoform X1

      UniProtKB/Swiss-Prot
      Q5PQR8
      UniProtKB/TrEMBL
      A6IAU0, A6IAU1, G3V805
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    2. XM_006236746.5 → XP_006236808.1  EKC/KEOPS complex subunit Tprkb isoform X1

      See identical proteins and their annotated locations for XP_006236808.1

      UniProtKB/Swiss-Prot
      Q5PQR8
      UniProtKB/TrEMBL
      A6IAU0, A6IAU1, G3V805
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    3. XM_063285808.1 → XP_063141878.1  EKC/KEOPS complex subunit Tprkb isoform X1

      UniProtKB/Swiss-Prot
      Q5PQR8
      UniProtKB/TrEMBL
      A6IAU0, A6IAU1, G3V805
      Related
      ENSRNOP00000066993.3, ENSRNOT00000074924.4

    4. XM_063285810.1 → XP_063141880.1  EKC/KEOPS complex subunit Tprkb isoform X1

      UniProtKB/Swiss-Prot
      Q5PQR8
      UniProtKB/TrEMBL
      A6IAU0, A6IAU1, G3V805

    5. XM_063285809.1 → XP_063141879.1  EKC/KEOPS complex subunit Tprkb isoform X1

      UniProtKB/Swiss-Prot
      Q5PQR8
      UniProtKB/TrEMBL
      A6IAU0, A6IAU1, G3V805

    6. XM_017593013.3 → XP_017448502.1  EKC/KEOPS complex subunit Tprkb isoform X1

      UniProtKB/Swiss-Prot
      Q5PQR8
      UniProtKB/TrEMBL
      A6IAU0, A6IAU1, G3V805
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    7. XM_006236743.5 → XP_006236805.1  EKC/KEOPS complex subunit Tprkb isoform X1

      See identical proteins and their annotated locations for XP_006236805.1

      UniProtKB/Swiss-Prot
      Q5PQR8
      UniProtKB/TrEMBL
      A6IAU0, A6IAU1, G3V805
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    8. XM_039107356.2 → XP_038963284.1  EKC/KEOPS complex subunit Tprkb isoform X1

      UniProtKB/Swiss-Prot
      Q5PQR8
      UniProtKB/TrEMBL
      A6IAU0, A6IAU1, G3V805
      Related
      ENSRNOP00000021211.3, ENSRNOT00000021211.8
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    9. XM_039107357.2 → XP_038963285.1  EKC/KEOPS complex subunit Tprkb isoform X1

      UniProtKB/Swiss-Prot
      Q5PQR8
      UniProtKB/TrEMBL
      A6IAU0, A6IAU1, G3V805
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121

    10. XM_039107359.2 → XP_038963287.1  EKC/KEOPS complex subunit Tprkb isoform X1

      UniProtKB/Swiss-Prot
      Q5PQR8
      UniProtKB/TrEMBL
      A6IAU0, A6IAU1, G3V805
      Conserved Domains (1) summary
      pfam08617
      Location:20 → 172
      CGI-121; Kinase binding protein CGI-121
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQR8.1 GenPept UniProtKB/Swiss-Prot:Q5PQR8

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