Bmi1 BMI1 proto-oncogene, polycomb ring finger [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bmi1provided by RGD
Official Full Name: BMI1 proto-oncogene, polycomb ring fingerprovided by RGD
Primary source: RGD:1307403
See related: EnsemblRapid:ENSRNOG00000016585 AllianceGenome:RGD:1307403
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pcgf4
Summary: Predicted to enable several functions, including RING-like zinc finger domain binding activity; promoter-specific chromatin binding activity; and zinc ion binding activity. Involved in cellular response to dexamethasone stimulus; cellular response to interleukin-1; and regulation of kidney development. Predicted to be located in cytosol; heterochromatin; and nuclear body. Predicted to be part of PRC1 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to several human genes including BMI1 (BMI1 proto-oncogene, polycomb ring finger). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 131.8), Heart (RPKM 108.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (86240683..86250044)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (81332175..81341625)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (85360439..85370283)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Localization of Bmi1 in osteoblast-lineage cells during endochondral ossification.
Title: Localization of Bmi1 in osteoblast-lineage cells during endochondral ossification.
In a rat model of radiotherapy-induced mucositis, Bmi1 upregulation was observed 8 days after irradiation. Consistently, Bmi1 was upregulated in HaCaT cells 1 h after irradiation, and its upregulation was in accord with X-ray exposure duration. the prognosis of s-OSCC is poorer as compared to p-OSCC, which may be attributed to Bmi1 upregulation.
Title: The poor outcome of second primary oral squamous cell carcinoma is attributed to Bmi1 upregulation.
We conclude that silencing of Bmi1 by miR-27b relieves repression of the presynaptic transcriptome and supports neurotransmission in cortical networks.
Title: miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1.
Thus modulation of Bmi1 expression in glial progenitors may represent a key event in determining the differentiation potential of these cells.
Title: Differentiation of postnatal cerebellar glial progenitors is controlled by Bmi1 through BMP pathway inhibition.

Submit: New GeneRIF Correction

General gene information

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Markers

M64279 (e-PCR)
- UniSTS:124972

RH136669 (e-PCR)
- UniSTS:218760

AI172222 (e-PCR)
- UniSTS:250590

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RING-like zinc finger domain binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activator activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA methylation-dependent constitutive heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within humoral immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immature T cell proliferation in thymus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of adaxial/abaxial pattern formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of kidney development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within rostrocaudal neural tube patterning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic stem cell division	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PRC1 complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polycomb complex protein BMI-1

Names: B lymphoma Mo-MLV insertion region 1; Bmi1 polycomb ring finger oncogene; polycomb group ring finger 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107368.2 → NP_001100838.1 polycomb complex protein BMI-1

See identical proteins and their annotated locations for NP_001100838.1

Status: PROVISIONAL

Source sequence(s)

BC168209

UniProtKB/TrEMBL

A6JM95, B4F7B6, F7FA44

Related

ENSRNOP00000103433.1, ENSRNOT00000126368.1

Conserved Domains (3) summary

PRK10803
Location:222 → 279

PRK10803; tol-pal system protein YbgF; Provisional

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17165
Location:130 → 224

RAWUL_PCGF4; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 4 (PCGF4)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

86240683..86250044

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095805.2 → XP_038951733.1 polycomb complex protein BMI-1 isoform X1

UniProtKB/TrEMBL

A6JM95, B4F7B6, F7FA44

Related

ENSRNOP00000059998.2, ENSRNOT00000064257.4

Conserved Domains (3) summary

PRK10803
Location:222 → 279

PRK10803; tol-pal system protein YbgF; Provisional

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17165
Location:130 → 224

RAWUL_PCGF4; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 4 (PCGF4)
XM_063276500.1 → XP_063132570.1 polycomb complex protein BMI-1 isoform X1

UniProtKB/TrEMBL

A6JM95, B4F7B6, F7FA44
XM_039095806.2 → XP_038951734.1 polycomb complex protein BMI-1 isoform X1

UniProtKB/TrEMBL

A6JM95, B4F7B6, F7FA44

Conserved Domains (3) summary

PRK10803
Location:222 → 279

PRK10803; tol-pal system protein YbgF; Provisional

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17165
Location:130 → 224

RAWUL_PCGF4; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 4 (PCGF4)
XM_039095807.2 → XP_038951735.1 polycomb complex protein BMI-1 isoform X1

UniProtKB/TrEMBL

A6JM95, B4F7B6, F7FA44

Conserved Domains (3) summary

PRK10803
Location:222 → 279

PRK10803; tol-pal system protein YbgF; Provisional

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17165
Location:130 → 224

RAWUL_PCGF4; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 4 (PCGF4)
XM_039095808.2 → XP_038951736.1 polycomb complex protein BMI-1 isoform X1

UniProtKB/TrEMBL

A6JM95, B4F7B6, F7FA44

Conserved Domains (3) summary

PRK10803
Location:222 → 279

PRK10803; tol-pal system protein YbgF; Provisional

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17165
Location:130 → 224

RAWUL_PCGF4; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 4 (PCGF4)
XM_063276501.1 → XP_063132571.1 polycomb complex protein BMI-1 isoform X1

UniProtKB/TrEMBL

A6JM95, B4F7B6, F7FA44