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    Tmem59l transmembrane protein 59-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306349, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem59lprovided by RGD
    Official Full Name
    transmembrane protein 59-likeprovided by RGD
    Primary source
    RGD:1305557
    See related
    EnsemblRapid:ENSRNOG00000022432 AllianceGenome:RGD:1305557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C19orf4; RGD1305557
    Summary
    Predicted to be involved in branching involved in ureteric bud morphogenesis. Predicted to be located in Golgi membrane. Orthologous to human TMEM59L (transmembrane protein 59 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 544.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem59l in Genome Data Viewer
    Location:
    16p14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18975217..18979354)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18941370..18945381)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20691956..20695701)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene required for excision 1-B domain containing Neighboring gene cytokine receptor-like factor 1 Neighboring gene kelch-like family member 26 Neighboring gene CREB regulated transcription coactivator 1 Neighboring gene uncharacterized LOC102549994

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death. Zheng Q, et al. Mol Neurobiol, 2017 Aug. PMID 27324899, Free PMC Article
    2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM59L is a pro-apoptotic neuronal protein involved in animal behaviors such as anxiety, depression, and memory.
      Title: The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 59-like
    Names
    brain-specific membrane-anchored protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271055.1 → NP_001257984.1  transmembrane protein 59-like precursor

      See identical proteins and their annotated locations for NP_001257984.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q5HZE8
      UniProtKB/TrEMBL
      A0A0H2UHT4, A6KA50
      Related
      ENSRNOP00000075600.2, ENSRNOT00000082319.3
      Conserved Domains (1) summary
      pfam12280
      Location:72 → 278
      BSMAP; Brain specific membrane anchored protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18975217..18979354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252897.5 → XP_006252959.1  transmembrane protein 59-like isoform X1

      UniProtKB/Swiss-Prot
      Q5HZE8
      UniProtKB/TrEMBL
      A0A0G2KB04
      Related
      ENSRNOP00000029378.6, ENSRNOT00000038139.8
      Conserved Domains (1) summary
      pfam12280
      Location:90 → 296
      BSMAP; Brain specific membrane anchored protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZE8.2 GenPept UniProtKB/Swiss-Prot:Q5HZE8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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