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    Enoph1 enolase-phosphatase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305177, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Enoph1provided by RGD
    Official Full Name
    enolase-phosphatase 1provided by RGD
    Primary source
    RGD:1309016
    See related
    AllianceGenome:RGD:1309016
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309016
    Summary
    Predicted to enable acireductone synthase activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be located in cytoplasm and nucleus. Orthologous to human ENOPH1 (enolase-phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 179.0), Brain (RPKM 157.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Enoph1 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (9835626..9862051, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (9531336..9557797, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (11172359..11198799, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481707 Neighboring gene transmembrane protein 150C Neighboring gene uncharacterized LOC134481706 Neighboring gene uncharacterized LOC134481708 Neighboring gene heterogeneous nuclear ribonucleoprotein D-like Neighboring gene heterogeneous nuclear ribonucleoprotein D Neighboring gene histone chaperone ASF1A-like Neighboring gene transcription factor BTF3-like Neighboring gene vesicle-associated membrane protein 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of human E1 enzyme and its complex with a substrate analog reveals the mechanism of its phosphatase/enolase activity. Wang H, et al. J Mol Biol, 2005 May 13. PMID 15843022
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC105720

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acireductone synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acireductone synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acireductone synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acireductone synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    enolase-phosphatase E1
    Names
    2,3-diketo-5-methylthio-1-phosphopentane phosphatase
    E-1 enzyme
    MASA homolog
    NP_001009391.1
    XP_017454658.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009391.1 → NP_001009391.1  enolase-phosphatase E1

      See identical proteins and their annotated locations for NP_001009391.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087697
      UniProtKB/Swiss-Prot
      Q5PPH0
      UniProtKB/TrEMBL
      A0A8I6ADH3, A6K613
      Conserved Domains (1) summary
      cd01629
      Location:12 → 231
      HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      9835626..9862051 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599169.3 → XP_017454658.1  enolase-phosphatase E1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PPH0.1 GenPept UniProtKB/Swiss-Prot:Q5PPH0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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