Itgb1bp1 integrin subunit beta 1 binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itgb1bp1provided by RGD
Official Full Name: integrin subunit beta 1 binding protein 1provided by RGD
Primary source: RGD:1307810
See related: EnsemblRapid:ENSRNOG00000059402 AllianceGenome:RGD:1307810
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GDP-dissociation inhibitor activity; integrin binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including regulation of cell migration; regulation of cell-substrate adhesion; and regulation of signal transduction. Predicted to be located in several cellular components, including centriolar satellite; nuclear body; and perinuclear region of cytoplasm. Predicted to be active in several cellular components, including cytoskeleton; lamellipodium; and ruffle. Orthologous to human ITGB1BP1 (integrin subunit beta 1 binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 133.2), Muscle (RPKM 125.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (46549994..46564735, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (40820693..40836074, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (43348927..43363633, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH141519 (e-PCR)
- UniSTS:223513

D6Got50 (e-PCR)
- UniSTS:115054

RH143075 (e-PCR)
- UniSTS:232322

BG372800 (e-PCR)
- UniSTS:248964

AI449260 (e-PCR)
- UniSTS:180371

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
involved_in blood vessel diameter maintenance	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in integrin activation	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in myoblast migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion involved in substrate-bound cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in tube formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
NOT located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin beta-1-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106719.2 → NP_001100189.1 integrin beta-1-binding protein 1

See identical proteins and their annotated locations for NP_001100189.1

Status: PROVISIONAL

Source sequence(s)

BC169104

UniProtKB/TrEMBL

A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3

Related

ENSRNOP00000071708.3, ENSRNOT00000092192.3

Conserved Domains (1) summary

cl17171
Location:1 → 199

PH-like; Pleckstrin homology-like domain
NM_001434252.1 → NP_001421181.1 integrin beta-1-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
NM_001434253.1 → NP_001421182.1 integrin beta-1-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
NM_001434254.1 → NP_001421183.1 integrin beta-1-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
NM_001434255.1 → NP_001421184.1 integrin beta-1-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
NM_001434256.1 → NP_001421185.1 integrin beta-1-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
NM_001434257.1 → NP_001421186.1 integrin beta-1-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

46549994..46564735 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006239980.5 → XP_006240042.1 integrin beta-1-binding protein 1 isoform X1

Conserved Domains (1) summary

cl17171
Location:1 → 199

PH-like; Pleckstrin homology-like domain
XM_039111953.2 → XP_038967881.1 integrin beta-1-binding protein 1 isoform X1

Conserved Domains (1) summary

cl17171
Location:1 → 199

PH-like; Pleckstrin homology-like domain
XM_039111951.2 → XP_038967879.1 integrin beta-1-binding protein 1 isoform X1

Conserved Domains (1) summary

cl17171
Location:1 → 199

PH-like; Pleckstrin homology-like domain
XM_006239979.5 → XP_006240041.1 integrin beta-1-binding protein 1 isoform X1

Conserved Domains (1) summary

cl17171
Location:1 → 199

PH-like; Pleckstrin homology-like domain
XM_006239981.5 → XP_006240043.1 integrin beta-1-binding protein 1 isoform X1

Conserved Domains (1) summary

cl17171
Location:1 → 199

PH-like; Pleckstrin homology-like domain
XM_063261656.1 → XP_063117726.1 integrin beta-1-binding protein 1 isoform X1
XM_039111952.2 → XP_038967880.1 integrin beta-1-binding protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3

Conserved Domains (1) summary

cl17171
Location:1 → 199

PH-like; Pleckstrin homology-like domain