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    Adamtsl3 ADAMTS-like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adamtsl3provided by RGD
    Official Full Name
    ADAMTS-like 3provided by RGD
    Primary source
    RGD:1305155
    See related
    EnsemblRapid:ENSRNOG00000010840 AllianceGenome:RGD:1305155
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in extracellular matrix organization. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular matrix. Orthologous to human ADAMTSL3 (ADAMTS like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 76.3), Heart (RPKM 61.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adamtsl3 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (145698004..146006195)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (136288793..136596986)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (144238958..144561065)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene SH3 domain containing GRB2 like 3, endophilin A3 Neighboring gene uncharacterized LOC134483750 Neighboring gene U6 snRNA-associated Sm-like protein LSm5 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene stabilizer of axonemal microtubules 2 Neighboring gene elongation factor like GTPase 1 Neighboring gene mex-3 RNA binding family member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADAMTS-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107533.2 → NP_001101003.2  ADAMTS-like protein 3

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D4ADD4
      Related
      ENSRNOP00000029738.7, ENSRNOT00000032106.8
      Conserved Domains (7) summary
      cd00096
      Location:1223 → 1291
      Ig; Immunoglobulin domain
      smart00408
      Location:1329 → 1387
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:90 → 136
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:1313 → 1392
      IG_like; Immunoglobulin like
      pfam00090
      Location:1502 → 1557
      TSP_1; Thrombospondin type 1 domain
      pfam08686
      Location:1673 → 1703
      PLAC; PLAC (protease and lacunin) domain
      cl11960
      Location:942 → 1006
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      145698004..146006195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229477.4 → XP_006229539.1  ADAMTS-like protein 3 isoform X1

      UniProtKB/TrEMBL
      D4ADD4
      Related
      ENSRNOP00000107619.1, ENSRNOT00000164876.1
      Conserved Domains (6) summary
      cd00096
      Location:1223 → 1291
      Ig; Immunoglobulin domain
      smart00408
      Location:1329 → 1387
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:90 → 136
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:1313 → 1392
      IG_like; Immunoglobulin like
      pfam00090
      Location:1502 → 1557
      TSP_1; Thrombospondin type 1 domain
      cl11960
      Location:942 → 1006
      Ig; Immunoglobulin domain

    2. XM_017589168.3 → XP_017444657.1  ADAMTS-like protein 3 isoform X2

      Related
      ENSRNOP00000102190.1, ENSRNOT00000134497.1
    Nucleotide Protein Strain
    Heading Accession and Version

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