U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Il13ra1 interleukin 13 receptor subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252963, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Il13ra1provided by RGD
    Official Full Name
    interleukin 13 receptor subunit alpha 1provided by RGD
    Primary source
    RGD:628741
    See related
    EnsemblRapid:ENSRNOG00000013170 AllianceGenome:RGD:628741
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables interleukin-13 receptor activity. Involved in positive regulation of B cell proliferation and positive regulation of immunoglobulin production. Human ortholog(s) of this gene implicated in asthma and chronic obstructive pulmonary disease. Orthologous to human IL13RA1 (interleukin 13 receptor subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 464.4), Lung (RPKM 287.8) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Il13ra1 in Genome Data Viewer
    Location:
    Xq34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (120213670..120294777)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (115348822..115408682)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (122724081..122783801)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15, pseudogene 3 Neighboring gene dedicator of cytokinesis 11 Neighboring gene uncharacterized LOC134484095 Neighboring gene zinc finger CCHC-type containing 12 Neighboring gene U6 spliceosomal RNA Neighboring gene LON peptidase N-terminal domain and ring finger 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Novel polymorphism in the coding region of the IL-13 receptor alpha' gene: association study with atopic asthma in the Japanese population. Ahmed S, et al. Exp Clin Immunogenet, 2000. PMID 10686479
    2. Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy. Konstantinidis AK, et al. Eur Respir J, 2007 Jul. PMID 17392323
    3. Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis. Wongpiyabovorn J, et al. J Dermatol Sci, 2003 Oct. PMID 14527737
    4. IL-13 fusion cytotoxin ameliorates chronic fungal-induced allergic airway disease in mice. Blease K, et al. J Immunol, 2001 Dec 1. PMID 11714828
    5. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Graham BB, et al. Am J Pathol, 2010 Sep. PMID 20671265, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC105309

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables interleukin-13 receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in interleukin-13-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of immunoglobulin production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    interleukin-13 receptor subunit alpha-1
    Names
    interleukin 13 receptor, alpha 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145789.3 → NP_665732.2  interleukin-13 receptor subunit alpha-1 precursor

      See identical proteins and their annotated locations for NP_665732.2

      Status: VALIDATED

      Source sequence(s)
      BC093615, JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2JZB2, Q561K3, Q8VHC2
      Conserved Domains (2) summary
      cd00063
      Location:225 → 335
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:127 → 221
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      120213670..120294777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279821.1 → XP_063135891.1  interleukin-13 receptor subunit alpha-1 isoform X1

      Related
      ENSRNOP00000087106.2, ENSRNOT00000112175.2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous