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    Tcte1 t-complex-associated testis expressed 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tcte1provided by RGD
    Official Full Name
    t-complex-associated testis expressed 1provided by RGD
    Primary source
    RGD:1305744
    See related
    EnsemblRapid:ENSRNOG00000065569 AllianceGenome:RGD:1305744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in flagellated sperm motility. Predicted to be located in sperm flagellum. Orthologous to human TCTE1 (t-complex-associated-testis-expressed 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 57.7), Testes (RPKM 54.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tcte1 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22961005..22979711, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (15463573..15482258, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17847866..17867276, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member B2 Neighboring gene NFKB inhibitor epsilon Neighboring gene transmembrane protein 151B Neighboring gene uncharacterized LOC108351892 Neighboring gene alanyl-tRNA synthetase 2, mitochondrial Neighboring gene spermatogenesis associated, serine-rich 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. Castaneda JM, et al. Proc Natl Acad Sci U S A, 2017 Jul 3. PMID 28630322, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynein regulatory complex subunit 5
    Names
    T-complex-associated testis-expressed protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108206.2 → NP_001101676.1  dynein regulatory complex subunit 5

      See identical proteins and their annotated locations for NP_001101676.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6ART2, A6JIZ8
      Related
      ENSRNOP00000096980.1, ENSRNOT00000114547.2
      Conserved Domains (2) summary
      cd00116
      Location:177 → 484
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:307 → 333
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      22961005..22979711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244539.5 → XP_006244601.1  dynein regulatory complex subunit 5 isoform X1

      Conserved Domains (2) summary
      cd00116
      Location:177 → 484
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:307 → 333
      LRR_RI; leucine-rich repeat [structural motif]

    2. XM_006244540.5 → XP_006244602.1  dynein regulatory complex subunit 5 isoform X1

      See identical proteins and their annotated locations for XP_006244602.1

      UniProtKB/TrEMBL
      A0A8I6ART2, A6JIZ8
      Conserved Domains (2) summary
      cd00116
      Location:177 → 484
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:307 → 333
      LRR_RI; leucine-rich repeat [structural motif]

    3. XM_039083535.2 → XP_038939463.1  dynein regulatory complex subunit 5 isoform X2

      Conserved Domains (1) summary
      cl39015
      Location:177 → 282
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    Nucleotide Protein Strain
    Heading Accession and Version

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