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    Tfg trafficking from ER to golgi regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360709, updated on 9-Dec-2024

    Summary

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    Symbol
    Tfgprovided by RGD
    Full Name
    trafficking from ER to golgi regulatorprovided by RGD
    Primary source
    RGD:1309751
    See related
    EnsemblRapid:ENSRNOG00000001633 AllianceGenome:RGD:1309751
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum exit site. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 57. Orthologous to human TFG (trafficking from ER to golgi regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 123.4), Adrenal (RPKM 119.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tfg in Genome Data Viewer
    Location:
    11q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (57354607..57381071)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (43885542..43911976)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (46180189..46206723)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-ribosomal protein eS31 fusion protein-like Neighboring gene ribosomal protein S27a, pseudogene 21 Neighboring gene transmembrane protein 45A Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene uncharacterized LOC134481066 Neighboring gene ABI family member 3 binding protein Neighboring gene uncharacterized LOC134481065 Neighboring gene cell cycle associated protein 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TFG regulates secretory and endosomal sorting pathways in neurons to promote their activity and maintenance. Peotter JL, et al. Proc Natl Acad Sci U S A, 2022 Oct 4. PMID 36161950, Free PMC Article
    2. The calcium-binding protein ALG-2 promotes endoplasmic reticulum exit site localization and polymerization of Trk-fused gene (TFG) protein. Kanadome T, et al. FEBS J, 2017 Jan. PMID 27813252
    3. TFG-1 function in protein secretion and oncogenesis. Witte K, et al. Nat Cell Biol, 2011 May. PMID 21478858, Free PMC Article
    4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
    5. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TFG regulates secretory and endosomal sorting pathways in neurons to promote their activity and maintenance.
      Title: TFG regulates secretory and endosomal sorting pathways in neurons to promote their activity and maintenance.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII vesicle coating IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein TFG
    Names
    TRK-fused gene protein
    protein TFG-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012144.1 → NP_001012144.1  protein TFG

      See identical proteins and their annotated locations for NP_001012144.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078947
      UniProtKB/TrEMBL
      A6IQP2, Q6AYR1
      Related
      ENSRNOP00000075029.3, ENSRNOT00000088152.3
      Conserved Domains (2) summary
      cd06401
      Location:11 → 91
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      PRK13335
      Location:328 → 398
      PRK13335; superantigen-like protein SSL3; Reviewed

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      57354607..57381071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248236.5 → XP_006248298.1  protein TFG isoform X2

      Conserved Domains (1) summary
      cd06401
      Location:11 → 91
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...

    2. XM_006248237.5 → XP_006248299.1  protein TFG isoform X3

      UniProtKB/TrEMBL
      A6IQP2
      Related
      ENSRNOP00000101121.1, ENSRNOT00000150031.1
      Conserved Domains (1) summary
      cd06401
      Location:11 → 91
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...

    3. XM_017598026.3 → XP_017453515.1  protein TFG isoform X4

      UniProtKB/TrEMBL
      A0A0G2K9K4, Q4R1A4
      Related
      ENSRNOP00000042252.4, ENSRNOT00000048417.6
      Conserved Domains (1) summary
      cd06401
      Location:11 → 91
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...

    4. XM_039088479.2 → XP_038944407.1  protein TFG isoform X5

      UniProtKB/TrEMBL
      A0A0G2K9K4
      Conserved Domains (1) summary
      cd06401
      Location:11 → 91
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...

    5. XM_039088480.2 → XP_038944408.1  protein TFG isoform X6

      UniProtKB/TrEMBL
      A0A0G2K9K4
      Conserved Domains (1) summary
      cd06401
      Location:11 → 91
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...

    6. XM_039088478.2 → XP_038944406.1  protein TFG isoform X1

      UniProtKB/TrEMBL
      A6IQP2, Q6AYR1
      Conserved Domains (2) summary
      cd06401
      Location:11 → 91
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      PRK13335
      Location:328 → 398
      PRK13335; superantigen-like protein SSL3; Reviewed

    7. XM_063270637.1 → XP_063126707.1  protein TFG isoform X3

      UniProtKB/TrEMBL
      A6IQP2

    RNA

    1. XR_010055962.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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