Hspa8 heat shock protein family A (Hsp70) member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hspa8provided by RGD
Official Full Name: heat shock protein family A (Hsp70) member 8provided by RGD
Primary source: RGD:621725
See related: EnsemblRapid:ENSRNOG00000034066 AllianceGenome:RGD:621725
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hsc70
Summary: Enables several functions, including A1 adenosine receptor binding activity; ATP hydrolysis activity; and adenyl ribonucleotide binding activity. Involved in several processes, including brain development; establishment of protein localization to organelle; and protein-containing complex disassembly. Acts upstream of or within protein-containing complex disassembly. Located in several cellular components, including dendrite; polymeric cytoskeletal fiber; and vacuole. Part of protein-containing complex. Is active in several cellular components, including glutamatergic synapse; glycinergic synapse; and postsynaptic density. Biomarker of Parkinson's disease; acute kidney failure; brain ischemia (multiple); disease of metabolism; and graft-versus-host disease. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: The functional gene for Hspa8 is located on Rno8. It was incorrectly placed on Rno5 on the reference assembly for NCBI Build 4.1 at the location of one of its pseudogenes. The correct GeneID for the pseudogene is geneID:100190885. [17 Jun 2014]
Expression: Biased expression in Brain (RPKM 7049.0), Kidney (RPKM 6652.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (50080514..50084376)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (41183397..41187260)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (44989401..44993261)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-3120/Hsc70 participates in forced swim stress-induced mechanical hyperalgesia in rats in an inflammatory state.
Title: miR‑3120/Hsc70 participates in forced swim stress‑induced mechanical hyperalgesia in rats in an inflammatory state.
Inhibition of heat shock protein family A member 8 attenuates spinal cord ischemia-reperfusion injury via astrocyte NF-kappaB/NLRP3 inflammasome pathway : HSPA8 inhibition protects spinal ischemia-reperfusion injury.
Title: Inhibition of heat shock protein family A member 8 attenuates spinal cord ischemia-reperfusion injury via astrocyte NF-κB/NLRP3 inflammasome pathway : HSPA8 inhibition protects spinal ischemia-reperfusion injury.
Carboxyl terminus of Hsc70-interacting protein (CHIP) promotes pulmonary artery smooth muscle cell (PASMC) proliferation via enhancement of intracellular Ca(2+) concentration ([Ca(2+)]i).
Title: Carboxyl terminus of Hsc70-interacting protein (CHIP) promotes pulmonary artery smooth muscle cell (PASMC) proliferation via enhancement of intracellular Ca(2+) concentration ([Ca(2+)](i)).
Hsc70 is required for E-cadherin expression in epithelial-like NRK-52E cells.
Title: Hsc70 is required for E-cadherin expression in epithelial-like NRK-52E cells.
HSPA8 is a Clcn2 accessory protein.
Title: Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes.
Study of intraventricular septum samples from hypertrophic cardiomyopathy patients and a panel of human MYBPC3 mutations expressed in neonatal rat ventricular cardiomyocytes revealed suggest that wild type and mutant MYBPC3 proteins are clients for HSC70, and that the HSC70 chaperone system plays a major role in regulating MYBPC3 protein turnover.
Title: HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C.
Synapsin is part of a multiprotein complex enriched in chaperones/cochaperones including Hsc70. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin.
Title: Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin.
these data demonstrate a novel interaction between Hsc70 and TH that regulates the activity and localization of the enzyme to synaptic vesicles, suggesting an important role for Hsc70 in dopamine homeostasis.
Title: The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization.
Pulsed electromagnetic wave exposure induced ultrastructural damage and the overexpression of HSP70 in the nuclei in the adenohypophysis.
Title: Pulsed electromagnetic wave exposure induces ultrastructural damage and upregulated expression of heat shock protein 70 in the rat adenohypophysis.
These findings demonstrate that Hsc70 chaperone activity is required for Rac1 activation by Trio and this function underlies netrin-1/DCC-dependent axon outgrowth and guidance.
Title: Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_24282-24283:1030043504:1 (e-PCR)
- UniSTS:268871

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables A1 adenosine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ADP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent protein disaggregase activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables C3HC4-type RING finger domain binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables clathrin-uncoating ATPase activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables prostaglandin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in axo-dendritic transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated autophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chaperone-mediated autophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chaperone-mediated autophagy translocation complex disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in chaperone-mediated protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in clathrin coat disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin coat disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in clathrin coat disassembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within clathrin coat disassembly	ISO Inferred from Sequence Orthology more info
involved_in clathrin coat disassembly	ISO Inferred from Sequence Orthology more info
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in forebrain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in late endosomal microautophagy	IEA Inferred from Electronic Annotation more info
involved_in late endosomal microautophagy	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in maintenance of postsynaptic specialization structure	EXP Inferred from Experiment more info	PubMed
involved_in maintenance of postsynaptic specialization structure	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of postsynaptic specialization structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of supramolecular fiber organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation by host of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of catalytic activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lysosomal membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein refolding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	ISO Inferred from Sequence Orthology more info
involved_in protein refolding	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transmembrane import into intracellular organelle	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within protein-containing complex disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein complex stability	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nickel cation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to odorant	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed
involved_in slow axonal transport	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of Prp19 complex	ISO Inferred from Sequence Orthology more info
part_of Prp19 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in asymmetric synapse	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in glycinergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glycinergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glycinergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glycinergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosomal lumen	TAS Traceable Author Statement more info
located_in lysosomal matrix	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in neuron spine	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor ribbon synapse	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor ribbon synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
part_of protein folding chaperone complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	HDA more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heat shock cognate 71 kDa protein

Names: Heat shock cognate protein 70; heat shock 70kD protein 8; heat shock 70kDa protein 8; heat shock protein 8; heat shock protein A8

NP_077327.1

EC 3.6.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.