Nlrp9 NLR family, pyrin domain containing 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nlrp9provided by RGD
Official Full Name: NLR family, pyrin domain containing 9provided by RGD
Primary source: RGD:1308981
See related: EnsemblRapid:ENSRNOG00000021913 AllianceGenome:RGD:1308981
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nalp9a; Nalp9b; Nlrp9b
Summary: Predicted to enable ATP binding activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of interleukin-18 production; and pyroptotic inflammatory response. Predicted to act upstream of or within blastocyst development. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Orthologous to human NLRP9 (NLR family pyrin domain containing 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1.1) See more
Orthologs: human all
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Genomic context

Location:: 1q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (77320034..77370366, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (68291180..68341512, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (71859390..71917337, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst development	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-18 production	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of canonical inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of canonical inflammasome complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 9

Names: NACHT, LRR and PYD containing protein 9a; NACHT, LRR and PYD containing protein 9b; NLR family, pyrin domain containing 9B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001169149.1 → NP_001162620.1 NACHT, LRR and PYD domains-containing protein 9

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6A735, D3ZAD9

Related

ENSRNOP00000108561.1, ENSRNOT00000154629.1

Conserved Domains (7) summary

cd08320
Location:9 → 90

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:694 → 722

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:893 → 920

LRR_AMN1; leucine-rich repeat [structural motif]

pfam17776
Location:440 → 555

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:385 → 430

NOD2_WH; NOD2 winged helix domain

cl39015
Location:691 → 956

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cl40481
Location:144 → 308

YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

77320034..77370366 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103829.1 → XP_038959757.1 NACHT, LRR and PYD domains-containing protein 9 isoform X1

UniProtKB/TrEMBL

A0A8I6A735

Related

ENSRNOP00000088910.1, ENSRNOT00000120223.2

Conserved Domains (7) summary

cd08320
Location:9 → 90

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:639 → 667

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:838 → 865

LRR_AMN1; leucine-rich repeat [structural motif]

pfam17776
Location:440 → 555

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:385 → 430

NOD2_WH; NOD2 winged helix domain

cl39015
Location:636 → 901

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cl40481
Location:144 → 308

YlqF_related_GTPase; Circularly permuted YlqF-related GTPases