Ece2 endothelin-converting enzyme 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ece2provided by RGD
Official Full Name: endothelin-converting enzyme 2provided by RGD
Primary source: RGD:1303039
See related: EnsemblRapid:ENSRNOG00000001715 AllianceGenome:RGD:1303039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide hormone processing. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including ECE2 (endothelin converting enzyme 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 59.3), Lung (RPKM 13.6) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11q23

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (93767559..93782896, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (80259130..80278446, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (83948896..83985429, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a role for differential modulation of opioid receptor signaling by post-endocytic processing of peptide agonists by ECE2.
Title: Opioid receptor function is regulated by post-endocytic peptide processing.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in peptide hormone processing	ISO Inferred from Sequence Orthology more info
involved_in peptide hormone processing	TAS Traceable Author Statement more info	PubMed
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endothelin-converting enzyme 2

NP_001002815.2

EC 3.4.24.71

XP_038944491.1

EC 3.4.24.71

XP_038944493.2

EC 3.4.24.71

XP_038944494.1

EC 3.4.24.71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002815.2 → NP_001002815.2 endothelin-converting enzyme 2

Status: VALIDATED

Source sequence(s)

BN000328, CB606217, JAXUCZ010000011

UniProtKB/TrEMBL

D4A4U1, Q6IE65

Related

ENSRNOP00000091720.2, ENSRNOT00000119768.2

Conserved Domains (2) summary

cd08662
Location:114 → 763

M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

COG3590
Location:103 → 756

PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

93767559..93782896 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088565.2 → XP_038944493.2 endothelin-converting enzyme 2 isoform X2

UniProtKB/TrEMBL

Q6IE65

Related

ENSRNOP00000079117.2, ENSRNOT00000093894.2
XM_039088563.2 → XP_038944491.1 endothelin-converting enzyme 2 isoform X1

UniProtKB/TrEMBL

Q6IE65

Conserved Domains (1) summary

cd08662
Location:101 → 750

M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
XM_039088566.2 → XP_038944494.1 endothelin-converting enzyme 2 isoform X3

Conserved Domains (1) summary

pfam05649
Location:116 → 502

Peptidase_M13_N; Peptidase family M13