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    Gpat2 glycerol-3-phosphate acyltransferase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpat2provided by RGD
    Official Full Name
    glycerol-3-phosphate acyltransferase 2, mitochondrialprovided by RGD
    Primary source
    RGD:1304904
    See related
    EnsemblRapid:ENSRNOG00000013906 AllianceGenome:RGD:1304904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304904
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity and glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidic acid biosynthetic process; piRNA processing; and triglyceride biosynthetic process. Predicted to act upstream of or within glycerol-3-phosphate metabolic process. Located in mitochondrial outer membrane. Orthologous to human GPAT2 (glycerol-3-phosphate acyltransferase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 38.4), Kidney (RPKM 9.8) and 8 other tissues See more
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    Genomic context

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    See Gpat2 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (135099751..135110355)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (114646446..114657051)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (119949921..120003090)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene astacin like metalloendopeptidase Neighboring gene adrenoceptor alpha 2B Neighboring gene fumarylacetoacetate hydrolase domain containing 2A Neighboring gene ribosomal protein L9, pseudogene 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glycerol-3-phosphate acyltransferase-2 is expressed in spermatic germ cells and incorporates arachidonic acid into triacylglycerols. Cattaneo ER, et al. PLoS One, 2012. PMID 22905194, Free PMC Article
    2. Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2). Wang S, et al. Arch Biochem Biophys, 2007 Sep 15. PMID 17689486, Free PMC Article
    3. Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondria. Lewin TM, et al. J Biol Chem, 2004 Apr 2. PMID 14724270
    4. GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells. Shiromoto Y, et al. RNA, 2013 Jun. PMID 23611983, Free PMC Article
    5. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. Chen YQ, et al. J Biol Chem, 2008 Apr 11. PMID 18238778, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPAT2 expression is linked to arachidonoyl-CoA incorporation into TAG in spermatogenic germ cells
      Title: Glycerol-3-phosphate acyltransferase-2 is expressed in spermatic germ cells and incorporates arachidonic acid into triacylglycerols.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within glycerol-3-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerophospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidic acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in piRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycerol-3-phosphate acyltransferase 2, mitochondrial
    Names
    1-acylglycerol-3-phosphate O-acyltransferase GPAT2
    NP_001162001.1
    XP_017447069.1
    XP_038960496.1
    XP_038960497.1
    XP_063139400.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168529.1 → NP_001162001.1  glycerol-3-phosphate acyltransferase 2, mitochondrial

      See identical proteins and their annotated locations for NP_001162001.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      D3ZI76
      UniProtKB/TrEMBL
      A0A8I5ZY97
      Related
      ENSRNOP00000106144.1, ENSRNOT00000155900.1
      Conserved Domains (1) summary
      cd07993
      Location:176 → 387
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      135099751..135110355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591580.2 → XP_017447069.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZY97
      Conserved Domains (1) summary
      cd07993
      Location:176 → 387
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    2. XM_039104569.1 → XP_038960497.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X3

      UniProtKB/Swiss-Prot
      D3ZI76
      UniProtKB/TrEMBL
      A0A8I5ZY97
      Related
      ENSRNOP00000018677.6, ENSRNOT00000018677.8
      Conserved Domains (1) summary
      cd07993
      Location:176 → 387
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    3. XM_039104568.1 → XP_038960496.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZY97
      Conserved Domains (1) summary
      cd07993
      Location:176 → 387
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    4. XM_063283330.1 → XP_063139400.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZY97

    RNA

    1. XR_005501820.1 RNA Sequence

    2. XR_010064581.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZI76.1 GenPept UniProtKB/Swiss-Prot:D3ZI76

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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