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    Polr2g RNA polymerase II subunit G [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117017, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr2gprovided by RGD
    Official Full Name
    RNA polymerase II subunit Gprovided by RGD
    Primary source
    RGD:621284
    See related
    EnsemblRapid:ENSRNOG00000019439 AllianceGenome:RGD:621284
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rpb7
    Summary
    Predicted to enable single-stranded DNA binding activity; single-stranded RNA binding activity; and translation initiation factor binding activity. Predicted to be involved in regulation of gene expression and transcription initiation at RNA polymerase II promoter. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Predicted to be active in P-body. Orthologous to human POLR2G (RNA polymerase II subunit G). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 300.5), Spleen (RPKM 218.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Polr2g in Genome Data Viewer
    Location:
    1q43
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215118278..215125389, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205689160..205692537, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (224991250..224998355, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 179B Neighboring gene interferon-induced transmembrane protein 2-like Neighboring gene TATA-box binding protein associated factor 6 like Neighboring gene zinc finger and BTB domain containing 3 Neighboring gene tetratricopeptide repeat domain 9C Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Microarray reveals complement components are regulated in the serum-deprived rat retinal ganglion cell line. Khalyfa A, et al. Mol Vis, 2007 Feb 28. PMID 17356516, Free PMC Article
    2. Structure and function of RNA polymerase II elongation factor ELL. Identification of two overlapping ELL functional domains that govern its interaction with polymerase and the ternary elongation complex. Shilatifard A, et al. J Biol Chem, 1997 Aug 29. PMID 9268387
    3. TFIIB-related factors in RNA polymerase I transcription. Knutson BA, et al. Biochim Biophys Acta, 2013 Mar-Apr. PMID 22960599, Free PMC Article
    4. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. Kershnar E, et al. J Biol Chem, 1998 Dec 18. PMID 9852112
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72732, MGC72993

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase II, core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase II subunit RPB7
    Names
    DNA-directed RNA polymerase II subunit G
    RNA polymerase II subunit B7
    polymerase (RNA) II (DNA directed) polypeptide G
    polymerase (RNA) II subunit G
    NP_446400.1
    XP_063122437.1
    XP_063122446.1
    XP_063122459.1
    XP_063122474.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053948.4 → NP_446400.1  DNA-directed RNA polymerase II subunit RPB7

      See identical proteins and their annotated locations for NP_446400.1

      Status: PROVISIONAL

      Source sequence(s)
      Z71925
      UniProtKB/Swiss-Prot
      P62489
      UniProtKB/TrEMBL
      A0A8I6GKH4, A6HZU1
      Related
      ENSRNOP00000026313.5, ENSRNOT00000026313.9
      Conserved Domains (1) summary
      PTZ00162
      Location:1 → 169
      PTZ00162; DNA-directed RNA polymerase II subunit 7; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215118278..215125389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266376.1 → XP_063122446.1  DNA-directed RNA polymerase II subunit RPB7 isoform X2

      UniProtKB/Swiss-Prot
      P62489
      UniProtKB/TrEMBL
      A0A8I6GKH4, A6HZU1

    2. XM_063266389.1 → XP_063122459.1  DNA-directed RNA polymerase II subunit RPB7 isoform X2

      UniProtKB/Swiss-Prot
      P62489
      UniProtKB/TrEMBL
      A0A8I6GKH4, A6HZU1

    3. XM_063266404.1 → XP_063122474.1  DNA-directed RNA polymerase II subunit RPB7 isoform X2

      UniProtKB/Swiss-Prot
      P62489
      UniProtKB/TrEMBL
      A0A8I6GKH4, A6HZU1

    4. XM_063266367.1 → XP_063122437.1  DNA-directed RNA polymerase II subunit RPB7 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKH4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62489.1 GenPept UniProtKB/Swiss-Prot:P62489

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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