Epb41l4b erythrocyte membrane protein band 4.1 like 4B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Epb41l4bprovided by RGD
Official Full Name: erythrocyte membrane protein band 4.1 like 4Bprovided by RGD
Primary source: RGD:1562988
See related: EnsemblRapid:ENSRNOG00000056550 AllianceGenome:RGD:1562988
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562988
Summary: Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in several processes, including actomyosin structure organization; positive regulation of keratinocyte migration; and wound healing. Predicted to be located in apical part of cell; cytosol; and plasma membrane. Predicted to be active in cytoskeleton. Orthologous to human EPB41L4B (erythrocyte membrane protein band 4.1 like 4B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 150.1), Kidney (RPKM 95.1) and 7 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5q24

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (76486886..76647752, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (71691706..71852583, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (74030950..74192275, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

AU049474 (e-PCR)
- UniSTS:145921

AU048092 (e-PCR)
- UniSTS:109880

RH128855 (e-PCR)
- UniSTS:212163

MARC_21252-21253:1032892750:1 (e-PCR)
- UniSTS:268517

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin structure organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actomyosin structure organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte migration	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in wound healing	IEA Inferred from Electronic Annotation more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: band 4.1-like protein 4B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127565.2 → NP_001121037.1 band 4.1-like protein 4B isoform 2

See identical proteins and their annotated locations for NP_001121037.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

B2RYE5

UniProtKB/TrEMBL

A0A0G2JU16

Related

ENSRNOP00000068924.2, ENSRNOT00000088169.3

Conserved Domains (5) summary

smart00295
Location:87 → 277

B41; Band 4.1 homologues

cd13186
Location:273 → 366

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam00373
Location:170 → 277

FERM_M; FERM central domain

pfam08736
Location:379 → 419

FA; FERM adjacent (FA)

pfam09379
Location:89 → 151

FERM_N; FERM N-terminal domain
NM_001401792.2 → NP_001388721.1 band 4.1-like protein 4B isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I6AAH9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

76486886..76647752 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110572.2 → XP_038966500.1 band 4.1-like protein 4B isoform X2

UniProtKB/TrEMBL

A0A0G2K3H4

Conserved Domains (3) summary

smart00295
Location:87 → 277

B41; Band 4.1 homologues

cd13186
Location:273 → 366

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam08736
Location:379 → 420

FA; FERM adjacent (FA)
XM_039110571.2 → XP_038966499.1 band 4.1-like protein 4B isoform X1

Related

ENSRNOP00000072639.3, ENSRNOT00000090366.3

Conserved Domains (3) summary

smart00295
Location:87 → 277

B41; Band 4.1 homologues

cd13186
Location:273 → 366

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam08736
Location:379 → 420

FA; FERM adjacent (FA)
XM_039110573.2 → XP_038966501.1 band 4.1-like protein 4B isoform X3

Related

ENSRNOP00000101921.1, ENSRNOT00000147948.1

Conserved Domains (3) summary

smart00295
Location:87 → 277

B41; Band 4.1 homologues

cd13186
Location:273 → 366

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam08736
Location:379 → 420

FA; FERM adjacent (FA)
XM_063288230.1 → XP_063144300.1 band 4.1-like protein 4B isoform X5
XM_063288229.1 → XP_063144299.1 band 4.1-like protein 4B isoform X4

UniProtKB/TrEMBL

A0A0G2JU16

Related

ENSRNOP00000088752.2, ENSRNOT00000102034.2