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    Slc9b1 solute carrier family 9 member B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc9b1provided by RGD
    Official Full Name
    solute carrier family 9 member B1provided by RGD
    Primary source
    RGD:1305087
    See related
    EnsemblRapid:ENSRNOG00000069829 AllianceGenome:RGD:1305087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nhedc1; Nhedc2; RGD1305087
    Summary
    Predicted to be involved in flagellated sperm motility; inorganic cation transmembrane transport; and regulation of intracellular pH. Predicted to be located in sperm principal piece. Orthologous to human SLC9B1 (solute carrier family 9 member B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 119.7), Brain (RPKM 9.1) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc9b1 in Genome Data Viewer
    Location:
    2q43
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (226442892..226502966)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (223769105..223818359)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (240527120..240581616)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene 3-hydroxybutyrate dehydrogenase 2 Neighboring gene solute carrier family 9 member B2 Neighboring gene uncharacterized LOC134485973 Neighboring gene small nucleolar RNA SNORA26 Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene ubiquitin-conjugating enzyme E2D 3 Neighboring gene mannosidase beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel testis-specific Na+/H+ exchanger is involved in sperm motility and fertility. Liu T, et al. Front Biosci (Elite Ed), 2010 Jan 1. PMID 20036903
    2. Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility. Chen SR, et al. Cell Death Dis, 2016 Mar 24. PMID 27010853, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium/hydrogen exchanger 9B1
    Names
    Na+/H+ exchanger domain containing 1
    Na+/H+ exchanger domain containing 2
    solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
    solute carrier family 9, subfamily B (cation proton antiporter 2), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173973.1 → NP_001167444.1  sodium/hydrogen exchanger 9B1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      F1LPN2
      Related
      ENSRNOP00000110456.1, ENSRNOT00000095000.2
      Conserved Domains (1) summary
      cl01133
      Location:145 → 496
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      226442892..226502966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282298.1 → XP_063138368.1  sodium/hydrogen exchanger 9B1 isoform X2

    2. XM_063282300.1 → XP_063138370.1  sodium/hydrogen exchanger 9B1 isoform X3

    3. XM_063282297.1 → XP_063138367.1  sodium/hydrogen exchanger 9B1 isoform X1

    4. XM_063282302.1 → XP_063138372.1  sodium/hydrogen exchanger 9B1 isoform X5

    5. XM_063282301.1 → XP_063138371.1  sodium/hydrogen exchanger 9B1 isoform X4

      UniProtKB/TrEMBL
      A6HVW8, B0BN84

    RNA

    1. XR_010063634.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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