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    Tial1 Tia1 cytotoxic granule-associated RNA binding protein-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361655, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tial1provided by RGD
    Official Full Name
    Tia1 cytotoxic granule-associated RNA binding protein-like 1provided by RGD
    Primary source
    RGD:1595845
    See related
    EnsemblRapid:ENSRNOG00000020271 AllianceGenome:RGD:1595845
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA 3'-UTR AU-rich region binding activity and protein-RNA adaptor activity. Predicted to be involved in negative regulation of cell population proliferation; positive regulation of hippo signaling; and positive regulation of miRNA-mediated gene silencing. Predicted to act upstream of or within germ cell development; positive regulation of stem cell proliferation; and stem cell division. Located in cytoplasmic stress granule. Part of ribonucleoprotein complex. Biomarker of transient cerebral ischemia. Orthologous to human TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 146.0), Brain (RPKM 139.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tial1 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (192438794..192475520, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (183008358..183045092, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199844854..199865843, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485178 Neighboring gene uncharacterized LOC103691239 Neighboring gene regulator of G-protein signaling 10 Neighboring gene uncharacterized LOC134485179 Neighboring gene 40S ribosomal protein S19 pseudogene Neighboring gene ribosomal protein S2, pseudogene 13 Neighboring gene uncharacterized LOC134483924

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immunohistochemical evidence for a crossed cholecystokinin corticostriatal pathway in the rat. Morino P, et al. Neurosci Lett, 1992 Dec 14. PMID 1300485
    2. RNA-binding protein TIAR is essential for primordial germ cell development. Beck AR, et al. Proc Natl Acad Sci U S A, 1998 Mar 3. PMID 9482885, Free PMC Article
    3. Expression of the RNA-binding protein TIAR is increased in neurons after ischemic cerebral injury. Jin K, et al. J Neurosci Res, 2000 Mar 15. PMID 10700014
    4. Alternative splicing: a pivotal step between eukaryotic transcription and translation. Kornblihtt AR, et al. Nat Rev Mol Cell Biol, 2013 Mar. PMID 23385723
    5. U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA. Zhu H, et al. Mol Cell Biol, 2003 Sep. PMID 12917321, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TIAR regulates the relative expression of TIA-1 isoforms.
      Title: Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109552

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR AU-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-RNA adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within germ cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of miRNA-mediated gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within stem cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleolysin TIAR
    Names
    RNA binding protein TIAR (TIA-1 related)
    Tial 1 cytotoxic granule-associated RNA- binding protein-like 1
    Tial1 cytotoxic granule-associated RNA binding protein-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013193.1 → NP_001013211.1  nucleolysin TIAR

      See identical proteins and their annotated locations for NP_001013211.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091409
      UniProtKB/TrEMBL
      A0A9K3Y710, F1LQ36, Q5BJN3
      Related
      ENSRNOP00000027463.5, ENSRNOT00000027463.7
      Conserved Domains (3) summary
      cd12620
      Location:222 → 294
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12616
      Location:10 → 107
      RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:113 → 192
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      192438794..192475520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083035.2 → XP_038938963.1  nucleolysin TIAR isoform X2

      Related
      ENSRNOP00000091228.2, ENSRNOT00000102400.2
      Conserved Domains (3) summary
      cd12620
      Location:166 → 238
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:57 → 136
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:1 → 51
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_006230310.5 → XP_006230372.1  nucleolysin TIAR isoform X1

      See identical proteins and their annotated locations for XP_006230372.1

      UniProtKB/TrEMBL
      A0A8I6GIU6, A6IA03
      Conserved Domains (3) summary
      cd12620
      Location:205 → 277
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12616
      Location:10 → 90
      RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:96 → 175
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

    3. XM_063267805.1 → XP_063123875.1  nucleolysin TIAR isoform X2

    4. XM_063267806.1 → XP_063123876.1  nucleolysin TIAR isoform X4

    5. XM_063267807.1 → XP_063123877.1  nucleolysin TIAR isoform X5

      UniProtKB/TrEMBL
      A6IA05

    6. XM_063267812.1 → XP_063123882.1  nucleolysin TIAR isoform X5

      UniProtKB/TrEMBL
      A6IA05

    7. XM_006230312.5 → XP_006230374.1  nucleolysin TIAR isoform X3

      See identical proteins and their annotated locations for XP_006230374.1

      Conserved Domains (3) summary
      cd12620
      Location:222 → 294
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12616
      Location:10 → 107
      RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:113 → 192
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

    8. XM_006230313.5 → XP_006230375.1  nucleolysin TIAR isoform X3

      See identical proteins and their annotated locations for XP_006230375.1

      Conserved Domains (3) summary
      cd12620
      Location:222 → 294
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12616
      Location:10 → 107
      RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:113 → 192
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

    RNA

    1. XR_010054659.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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