Npffr1 neuropeptide FF receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Npffr1provided by RGD
Official Full Name: neuropeptide FF receptor 1provided by RGD
Primary source: RGD:621570
See related: EnsemblRapid:ENSRNOG00000000559 AllianceGenome:RGD:621570
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NPFF1; Gpr147; OT7T022
Summary: Enables neuropeptide receptor activity. Involved in neuropeptide signaling pathway. Predicted to be active in cilium and plasma membrane. Orthologous to human NPFFR1 (neuropeptide FF receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 6.3), Brain (RPKM 5.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (30082604..30116752)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (29539795..29573951)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (31214950..31248710)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adult females, as compared with males, have significantly more RFRP-1-ir per cell, and these cells are regulated during the estrous cycle.
Title: Changes in RFamide-related peptide-1 (RFRP-1)-immunoreactivity during postnatal development and the estrous cycle.
Rfrp (GnIH)-expressing neurons serve as potential upstream mediators of stress-induced effects through Gpr147 (GnIH-R)-dependent mechanisms.
Title: Glucocorticoid receptor-mediated regulation of Rfrp (GnIH) and Gpr147 (GnIH-R) synthesis in immortalized hypothalamic neurons.
two central controllers of reproductive function, gonadotropin-releasing hormone (GnRH) and kisspeptin, stimulate the expression of Gonadotropin-inhibitory hormone (GnIH) receptors in pituitary gonadotroph cells and hypothalamic GnRH neurons
Title: Expression of gonadotropin-inhibitory hormone receptors in mouse pituitary gonadotroph LβT2 cells and hypothalamic gonadotropin-releasing hormone-producing GT1-7 cells.
RFRP-1 injected into the central nucleus of the rat amygdala decreases food intake. This is a NPFF-1 linked effect, because it could be prevented by NPFF-receptor antagonist RF9.
Title: Microinjection of RFRP-1 in the central nucleus of amygdala decreases food intake in the rat.
Developmental and steroidogenic effects on the gene expression of RFamide related peptides and their receptor in the rat brain and pituitary gland.
Title: Developmental and steroidogenic effects on the gene expression of RFamide related peptides and their receptor in the rat brain and pituitary gland.
The constant presence of NPFF1 receptors in the septum, the nucleus of the tractus solitarius, and the hypothalamus suggest its participation in neuroendocrine functions.
Title: Detailed distribution of neuropeptide FF receptors (NPFF1 and NPFF2) in the rat, mouse, octodon, rabbit, guinea pig, and marmoset monkey brains: a comparative autoradiographic study.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuropeptide FF receptor 1

Names: G-protein coupled receptor 147; RFamide-related peptide receptor OT7T022

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022291.2 → NP_071627.2 neuropeptide FF receptor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q9EP86

UniProtKB/TrEMBL

F1LN94

Related

ENSRNOP00000000675.3, ENSRNOT00000000675.5

Conserved Domains (2) summary

pfam00001
Location:60 → 331

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:54 → 173

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

30082604..30116752

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256485.5 → XP_006256547.1 neuropeptide FF receptor 1 isoform X1

UniProtKB/Swiss-Prot

Q9EP86

Related

ENSRNOP00000096765.1, ENSRNOT00000115618.2

Conserved Domains (2) summary

pfam00001
Location:96 → 367

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:90 → 209

7tm_4; Olfactory receptor
XM_063279491.1 → XP_063135561.1 neuropeptide FF receptor 1 isoform X2