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    Angptl6 angiopoietin-like 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298698, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Angptl6provided by RGD
    Official Full Name
    angiopoietin-like 6provided by RGD
    Primary source
    RGD:1311141
    See related
    EnsemblRapid:ENSRNOG00000020603 AllianceGenome:RGD:1311141
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be located in secretory granule. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human ANGPTL6 (angiopoietin like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 103.0), Brain (RPKM 18.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Angptl6 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (27689804..27696172, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19413617..19419925, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (21895523..21902002, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene collagen type V alpha 3 chain Neighboring gene retinol dehydrogenase 8 Neighboring gene shiftless antiviral inhibitor of ribosomal frameshifting Neighboring gene small nucleolar RNA, C/D box 105B Neighboring gene small nucleolar RNA, C/D box 105 Neighboring gene peter pan homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Angiopoietin-related growth factor (AGF) promotes angiogenesis. Oike Y, et al. Blood, 2004 May 15. PMID 14764539
    2. Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. Oike Y, et al. Proc Natl Acad Sci U S A, 2003 Aug 5. PMID 12871997, Free PMC Article
    3. Relationship of ANGPTL6 With Neonatal Glucose Homeostasis and Fat Mass Is Disrupted in Gestational Diabetic Pregnancies. Valencia-Martínez A, et al. J Clin Endocrinol Metab, 2022 Sep 28. PMID 35876300
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    angiopoietin-related protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106702.1 → NP_001100172.1  angiopoietin-related protein 6 precursor

      See identical proteins and their annotated locations for NP_001100172.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473993
      UniProtKB/TrEMBL
      A6JNL9, B2RYM1, F1LME9
      Related
      ENSRNOP00000027963.6, ENSRNOT00000027963.8
      Conserved Domains (2) summary
      cd00087
      Location:242 → 453
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam04871
      Location:66 → 157
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      27689804..27696172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265038.1 → XP_063121108.1  angiopoietin-related protein 6 isoform X1

    2. XM_039080978.2 → XP_038936906.1  angiopoietin-related protein 6 isoform X2

      Conserved Domains (1) summary
      cd00087
      Location:70 → 281
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    3. XM_063265039.1 → XP_063121109.1  angiopoietin-related protein 6 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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