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    Inpp1 inositol polyphosphate-1-phosphatase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316376, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Inpp1provided by RGD
    Official Full Name
    inositol polyphosphate-1-phosphataseprovided by RGD
    Primary source
    RGD:1306071
    See related
    EnsemblRapid:ENSRNOG00000012375 AllianceGenome:RGD:1306071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable inositol-1,4-bisphosphate 1-phosphatase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Orthologous to human INPP1 (inositol polyphosphate-1-phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 68.7), Lung (RPKM 61.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Inpp1 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (56161816..56209774)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (48688037..48717793)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (53544602..53574303)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene serine and arginine rich splicing factor 7, pseudogene 4 Neighboring gene 3-hydroxyisobutyryl-CoA hydrolase Neighboring gene post-GPI attachment to proteins 2, pseudogene 2 Neighboring gene BCL2 interacting protein 3, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inositol polyphosphate 1-phosphatase
    NP_001012131.1
    XP_006244961.1
    XP_008765313.1
    XP_008765314.1
    XP_038939520.1
    XP_038939523.1
    XP_063123238.1
    XP_063123239.1
    XP_063123240.1
    XP_063123242.1
    XP_063123243.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012131.2 → NP_001012131.1  inositol polyphosphate 1-phosphatase isoform 1

      See identical proteins and their annotated locations for NP_001012131.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6ALU7, A0A8I6GJG8, A6INV6, Q5RJK6
      Related
      ENSRNOP00000091276.1, ENSRNOT00000112625.2
      Conserved Domains (1) summary
      cd01640
      Location:4 → 384
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    2. NM_001432655.1 → NP_001419584.1  inositol polyphosphate 1-phosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6ALU7, A0A8I6GJG8, A6INV6, Q5RJK6

    3. NM_001432664.1 → NP_001419593.1  inositol polyphosphate 1-phosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6ALU7, A0A8I6GJG8, A6INV6, Q5RJK6

    4. NM_001432665.1 → NP_001419594.1  inositol polyphosphate 1-phosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6ALU7, A0A8I6GJG8, A6INV6, Q5RJK6

    5. NM_001432666.1 → NP_001419595.1  inositol polyphosphate 1-phosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6ALU7, A0A8I6GJG8, A6INV6, Q5RJK6

    6. NM_001432667.1 → NP_001419596.1  inositol polyphosphate 1-phosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6ALU7, A0A8I6GJG8, A6INV6, Q5RJK6

    7. NM_001432668.1 → NP_001419597.1  inositol polyphosphate 1-phosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6ALU7, A0A8I6GJG8, A6INV6, Q5RJK6

    8. NM_001432669.1 → NP_001419598.1  inositol polyphosphate 1-phosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6ALU7, A0A8I6GJG8, A6INV6, Q5RJK6

    9. NM_001432670.1 → NP_001419599.1  inositol polyphosphate 1-phosphatase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    10. NM_001432671.1 → NP_001419600.1  inositol polyphosphate 1-phosphatase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    11. NM_001432672.1 → NP_001419601.1  inositol polyphosphate 1-phosphatase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    12. NM_001432673.1 → NP_001419602.1  inositol polyphosphate 1-phosphatase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    13. NM_001432674.1 → NP_001419603.1  inositol polyphosphate 1-phosphatase isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      56161816..56209774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267168.1 → XP_063123238.1  inositol polyphosphate 1-phosphatase isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJG8, F7FA04
      Related
      ENSRNOP00000016842.5, ENSRNOT00000016842.7

    2. XM_063267169.1 → XP_063123239.1  inositol polyphosphate 1-phosphatase isoform X3

    3. XM_039083592.2 → XP_038939520.1  inositol polyphosphate 1-phosphatase isoform X2

      Conserved Domains (1) summary
      cd01640
      Location:4 → 384
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    4. XM_063267170.1 → XP_063123240.1  inositol polyphosphate 1-phosphatase isoform X4

    5. XM_039083595.2 → XP_038939523.1  inositol polyphosphate 1-phosphatase isoform X5

      Conserved Domains (1) summary
      cl00289
      Location:48 → 276
      FIG; FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in ...

    6. XM_006244899.5 → XP_006244961.1  inositol polyphosphate 1-phosphatase isoform X2

      Related
      ENSRNOP00000096460.1, ENSRNOT00000109452.2
      Conserved Domains (1) summary
      cd01640
      Location:4 → 384
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    7. XM_008767092.3 → XP_008765314.1  inositol polyphosphate 1-phosphatase isoform X2

      Conserved Domains (1) summary
      cd01640
      Location:4 → 384
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    8. XM_063267172.1 → XP_063123242.1  inositol polyphosphate 1-phosphatase isoform X4

    9. XM_063267173.1 → XP_063123243.1  inositol polyphosphate 1-phosphatase isoform X4

    10. XM_008767091.4 → XP_008765313.1  inositol polyphosphate 1-phosphatase isoform X2

      Conserved Domains (1) summary
      cd01640
      Location:4 → 384
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
    Nucleotide Protein Strain
    Heading Accession and Version

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