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    Krtdap keratinocyte differentiation associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65186, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Krtdapprovided by RGD
    Official Full Name
    keratinocyte differentiation associated proteinprovided by RGD
    Primary source
    RGD:71086
    See related
    EnsemblRapid:ENSRNOG00000062262 AllianceGenome:RGD:71086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kdap
    Summary
    Involved in epidermis development. Predicted to be located in lamellar body. Predicted to be active in extracellular space. Orthologous to human KRTDAP (keratinocyte differentiation associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 100.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Krtdap in Genome Data Viewer
    Location:
    1q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95165844..95169025)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86038296..86041594)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89234689..89235610)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene suprabasin Neighboring gene dermokine Neighboring gene uncharacterized LOC134485108 Neighboring gene ribosomal protein L36 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of Kdap, a protein secreted by keratinocytes. Tsuchida S, et al. J Invest Dermatol, 2004 May. PMID 15140226
    2. Kdap, a novel gene associated with the stratification of the epithelium. Oomizu S, et al. Gene, 2000 Oct 3. PMID 11054531
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epidermis development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epidermis development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellar body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    keratinocyte differentiation-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399867.1 → NP_001386796.1  keratinocyte differentiation-associated protein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95165844..95169025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093979.2 → XP_038949907.1  keratinocyte differentiation-associated protein isoform X1

      UniProtKB/Swiss-Prot
      P85411
      Related
      ENSRNOP00000100576.1, ENSRNOT00000144610.1
      Conserved Domains (1) summary
      pfam15200
      Location:24 → 98
      KRTDAP; Keratinocyte differentiation-associated

    2. XM_063272964.1 → XP_063129034.1  keratinocyte differentiation-associated protein isoform X3

    3. XM_063272956.1 → XP_063129026.1  keratinocyte differentiation-associated protein isoform X2

      Related
      ENSRNOP00000106350.1, ENSRNOT00000123644.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P85411.1 GenPept UniProtKB/Swiss-Prot:P85411

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.