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    Gjc1 gap junction protein, gamma 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266706, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gjc1provided by RGD
    Official Full Name
    gap junction protein, gamma 1provided by RGD
    Primary source
    RGD:628889
    See related
    EnsemblRapid:ENSRNOG00000048838 AllianceGenome:RGD:628889
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cx45; Cxnq; Gja7
    Summary
    Enables gap junction channel activity. Involved in cell-cell signaling. Located in gap junction. Orthologous to human GJC1 (gap junction protein gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905923.1 and NW_007905924.1 in NCBI's Rattus norvegicus Annotation Release 105. [18 Jun 2015]
    Expression
    Biased expression in Muscle (RPKM 98.0), Heart (RPKM 95.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gjc1 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88262840..88285646, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87758192..87785443, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90781408..90912440, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095185 Neighboring gene DBF4B-CDC7 kinase regulatory subunit Neighboring gene ADAM metallopeptidase domain 11 Neighboring gene HIG1 hypoxia inducible domain family, member 1B Neighboring gene elongation factor Tu GTP binding domain containing 2 Neighboring gene dynein axonemal assembly factor 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Primary structure, organization, and expression of the rat connexin45 gene. Teunissen BE, et al. DNA Cell Biol, 2007 Feb. PMID 17328669
    2. Connexin45 gap junction channels in rat cerebral vascular smooth muscle cells. Li X, et al. Am J Physiol Heart Circ Physiol, 2001 Nov. PMID 11668048
    3. Overexpression of connexin 45 in rat mesenchymal stem cells improves the function as cardiac biological pacemakers. Tong M, et al. Chin Med J (Engl), 2010 Jun. PMID 20819514
    4. Sex-specific effects of metformin and liraglutide on renal pathology and expression of connexin 45 and pannexin 1 following long-term high-fat high-sugar diet. Luetić M, et al. Acta Histochem, 2021 Dec. PMID 34808525
    5. Rapid upregulation of the hippocampal connexins 36 and 45 mRNA levels during memory consolidation. Beheshti S, et al. Behav Brain Res, 2017 Mar 1. PMID 27913256

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sex-specific effects of metformin and liraglutide on renal pathology and expression of connexin 45 and pannexin 1 following long-term high-fat high-sugar diet.
      Title: Sex-specific effects of metformin and liraglutide on renal pathology and expression of connexin 45 and pannexin 1 following long-term high-fat high-sugar diet.
    2. Cx45-puncta in the cerebellar molecular layer were co-localized with Cx36-puncta and additionally occurred along Bergmann glial processes adjacent to Cx43-puncta. Expression of both Cx43 and Cx45 in Bergmann glia of rat may contribute to the complex properties of junctional coupling between these cells and perhaps to their reported coupling with Purkinje cells.
      Title: Cx36, Cx43 and Cx45 in mouse and rat cerebellar cortex: species-specific expression, compensation in Cx36 null mice and co-localization in neurons vs. glia.
    3. The results of the present study revealed that during memory consolidation in a passive avoidance paradigm, a rapid upregulation of Cx45 mRNAs level occurs in the hippocampus, which declines to the control level by 24 h after training.
      Title: Rapid upregulation of the hippocampal connexins 36 and 45 mRNA levels during memory consolidation.
    4. Changes in connexins, including Cx36, Cx43, and Cx45, may contribute to the damage process.
      Title: Gap junction proteins in the light-damaged albino rat.
    5. The absence of Cx43/Cx45 hemichannels in skeltal muscles cells greatly attenuates the inflammasome activation and muscle atrophy.
      Title: De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy.
    6. Findings demonstrate that overexpression of connexin 45 and subsequent formation of heteromeric connexin 45/connexin 43 gap junction channels in HCN4 expressing MSCs can improve their function as cardiac biological pacemakers in vitro.
      Title: Overexpression of connexin 45 in rat mesenchymal stem cells improves the function as cardiac biological pacemakers.
    7. Data show heterogeneous expression of the 3 Cx isoforms Cx43, Cx45, and Cx40 in heart.
      Title: [Quantitative connexin mRNA detection in posterior nodal extension of adult rat heart].
    8. Report regulation of connexin 45 gene expression during skeletal muscle regeneration in the adult rat.
      Title: Regulation of connexin gene expression during skeletal muscle regeneration in the adult rat.
    9. a cross-talk between CFTR and a variety of gap junction channels. Cytoskeletal scaffolding proteins and/or other intermediate cytoplasmic proteins are likely to play a role in CFTR-connexins interaction.
      Title: Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes.
    10. Structural remodelling of gap junction connexin proteins may partly underlie electrophysiological defects in STZ-induced diabetic rat sinus atrial node.
      Title: Altered expression of gap junction connexin proteins may partly underlie heart rhythm disturbances in the streptozotocin-induced diabetic rat heart.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in AV node cell to bundle of His cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gap junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of connexin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of connexin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in gap junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gap junction gamma-1 protein
    Names
    connexin q
    connexin-45
    gap junction alpha-7 protein
    gap junction channel protein connexin 45
    gap junction membrane channel protein alpha 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085381.2 → NP_001078850.1  gap junction gamma-1 protein

      See identical proteins and their annotated locations for NP_001078850.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      A4GG66
      UniProtKB/TrEMBL
      A0A654ICN4, Q8CJ21
      Related
      ENSRNOP00000107543.1, ENSRNOT00000160044.1
      Conserved Domains (1) summary
      pfam00029
      Location:2 → 255
      Connexin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      88262840..88285646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597049.3 → XP_017452538.1  gap junction gamma-1 protein isoform X1

      UniProtKB/Swiss-Prot
      A4GG66
      UniProtKB/TrEMBL
      A0A654ICN4, Q8CJ21
      Related
      ENSRNOP00000076255.1, ENSRNOT00000093570.3
      Conserved Domains (1) summary
      pfam00029
      Location:2 → 255
      Connexin

    2. XM_039085312.2 → XP_038941240.1  gap junction gamma-1 protein isoform X1

      UniProtKB/Swiss-Prot
      A4GG66
      UniProtKB/TrEMBL
      A0A654ICN4, Q8CJ21
      Conserved Domains (1) summary
      pfam00029
      Location:2 → 255
      Connexin

    3. XM_039085309.2 → XP_038941237.1  gap junction gamma-1 protein isoform X1

      UniProtKB/Swiss-Prot
      A4GG66
      UniProtKB/TrEMBL
      A0A654ICN4, Q8CJ21
      Related
      ENSRNOP00000099947.1, ENSRNOT00000170911.1
      Conserved Domains (1) summary
      pfam00029
      Location:2 → 255
      Connexin

    4. XM_039085311.2 → XP_038941239.1  gap junction gamma-1 protein isoform X1

      UniProtKB/Swiss-Prot
      A4GG66
      UniProtKB/TrEMBL
      A0A654ICN4, Q8CJ21
      Conserved Domains (1) summary
      pfam00029
      Location:2 → 255
      Connexin

    5. XM_063268492.1 → XP_063124562.1  gap junction gamma-1 protein isoform X1

      UniProtKB/Swiss-Prot
      A4GG66
      UniProtKB/TrEMBL
      A0A654ICN4, Q8CJ21
      Related
      ENSRNOP00000087322.1, ENSRNOT00000108179.2

    6. XM_039085310.2 → XP_038941238.1  gap junction gamma-1 protein isoform X1

      UniProtKB/Swiss-Prot
      A4GG66
      UniProtKB/TrEMBL
      A0A654ICN4, Q8CJ21
      Related
      ENSRNOP00000096467.1, ENSRNOT00000116881.2
      Conserved Domains (1) summary
      pfam00029
      Location:2 → 255
      Connexin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4GG66.1 GenPept UniProtKB/Swiss-Prot:A4GG66

    Gene LinkOut

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