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    Gpc5 glypican 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306157, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gpc5provided by RGD
    Official Full Name
    glypican 5provided by RGD
    Primary source
    RGD:1308835
    See related
    EnsemblRapid:ENSRNOG00000071105 AllianceGenome:RGD:1308835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cell migration; positive regulation of canonical Wnt signaling pathway; and regulation of protein localization to membrane. Predicted to be located in collagen-containing extracellular matrix; plasma membrane; and side of membrane. Predicted to be active in cell surface. Orthologous to human GPC5 (glypican 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 101.8), Thymus (RPKM 11.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpc5 in Genome Data Viewer
    Location:
    15q23-q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (98614499..100051285)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (92207275..93644054)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (100283131..101776838)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548462 Neighboring gene 40S ribosomal protein S16-like Neighboring gene microRNA 19b-1 Neighboring gene microRNA 92a-1 Neighboring gene uncharacterized LOC134482015 Neighboring gene uncharacterized LOC134482016 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene 60S ribosomal protein L10-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120097177 Neighboring gene uncharacterized LOC134482019 Neighboring gene uncharacterized LOC134482018 Neighboring gene glypican 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Williams EH, et al. Proc Natl Acad Sci U S A, 2010 Mar 30. PMID 20231458, Free PMC Article
    2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glypican-5

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107285.2 → NP_001100755.2  glypican-5 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6ACQ6
      Related
      ENSRNOP00000104282.1, ENSRNOT00000161833.1
      Conserved Domains (1) summary
      pfam01153
      Location:12 → 569
      Glypican; Glypican

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      98614499..100051285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093413.2 → XP_038949341.1  glypican-5 isoform X2

      Conserved Domains (1) summary
      pfam01153
      Location:1 → 497
      Glypican

    2. XM_039093414.2 → XP_038949342.1  glypican-5 isoform X2

      Conserved Domains (1) summary
      pfam01153
      Location:1 → 497
      Glypican

    3. XM_063274345.1 → XP_063130415.1  glypican-5 isoform X2

    4. XM_039093412.2 → XP_038949340.1  glypican-5 isoform X1

      UniProtKB/TrEMBL
      A6HUE6
      Conserved Domains (1) summary
      pfam01153
      Location:93 → 496
      Glypican
    Nucleotide Protein Strain
    Heading Accession and Version

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