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    Lrrc1 leucine rich repeat containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367113, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Lrrc1provided by RGD
    Official Full Name
    leucine rich repeat containing 1provided by RGD
    Primary source
    RGD:1549773
    See related
    EnsemblRapid:ENSRNOG00000005970 AllianceGenome:RGD:1549773
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; protein localization to postsynapse; and receptor clustering. Predicted to be located in cytosol. Predicted to be active in adherens junction; basolateral plasma membrane; and postsynaptic density. Predicted to colocalize with postsynaptic membrane. Orthologous to human LRRC1 (leucine rich repeat containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 167.8), Kidney (RPKM 113.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (87120281..87289748, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (78239897..78407347, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (84721621..84835074, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene tubulointerstitial nephritis antigen Neighboring gene muscular LMNA-interacting protein Neighboring gene uncharacterized LOC120094211 Neighboring gene uncharacterized LOC108351748

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3. Wang Y, et al. Int J Mol Sci, 2024 Feb 27. PMID 38473980, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
      Title: The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter receptor transport postsynaptic membrane to endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014268.1 → NP_001014290.1  leucine-rich repeat-containing protein 1

      See identical proteins and their annotated locations for NP_001014290.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079423
      UniProtKB/TrEMBL
      A6I1G1, Q6AXP5
      Related
      ENSRNOP00000007867.5, ENSRNOT00000007867.7
      Conserved Domains (3) summary
      COG4886
      Location:39 → 412
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:33 → 232
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:61 → 83
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      87120281..87289748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081880.2 → XP_038937808.1  leucine-rich repeat-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6I1G1
      Related
      ENSRNOP00000089048.1, ENSRNOT00000104526.2
      Conserved Domains (2) summary
      PRK15370
      Location:26 → 285
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:61 → 83
      LRR_RI; leucine-rich repeat [structural motif]

    2. XM_063265888.1 → XP_063121958.1  leucine-rich repeat-containing protein 1 isoform X4

    3. XM_039081882.2 → XP_038937810.1  leucine-rich repeat-containing protein 1 isoform X3

      Conserved Domains (2) summary
      COG4886
      Location:123 → 281
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:133 → 155
      LRR_RI; leucine-rich repeat [structural motif]

    4. XM_039081881.2 → XP_038937809.1  leucine-rich repeat-containing protein 1 isoform X2

      Conserved Domains (2) summary
      COG4886
      Location:123 → 281
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:133 → 155
      LRR_RI; leucine-rich repeat [structural motif]

    RNA

    1. XR_010054010.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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