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    Crot carnitine O-octanoyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83842, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Crotprovided by RGD
    Official Full Name
    carnitine O-octanoyltransferaseprovided by RGD
    Primary source
    RGD:70908
    See related
    EnsemblRapid:ENSRNOG00000006779 AllianceGenome:RGD:70908
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables carnitine O-octanoyltransferase activity. Involved in response to xenobiotic stimulus. Located in peroxisome. Orthologous to human CROT (carnitine O-octanoyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 573.1), Kidney (RPKM 269.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Crot in Genome Data Viewer
    Location:
    4q12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (26031729..26088057)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (25068270..25133111)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (22079837..22116265)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3, subunit K, pseudogene 1 Neighboring gene uncharacterized LOC134486666 Neighboring gene uncharacterized protein C11orf98 homolog Neighboring gene uncharacterized LOC120102221 Neighboring gene ATP binding cassette subfamily B member 4 Neighboring gene uncharacterized LOC120102222 Neighboring gene ATP-binding cassette, sub-family B member 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and sequence analysis of the rat liver carnitine octanoyltransferase cDNA, its natural gene and the gene promoter. Choi SJ, et al. Biochim Biophys Acta, 1995 Nov 7. PMID 7495866
    2. Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver. Miyazawa S, et al. J Biochem, 1983 Aug. PMID 6630173
    3. Cloning, sequencing, and regulation of rat liver carnitine octanoyltransferase: transcriptional stimulation of the enzyme during peroxisome proliferation. Chatterjee B, et al. Biochemistry, 1988 Dec 13. PMID 3233218
    4. Changes in carnitine octanoyltransferase activity induce alteration in fatty acid metabolism. Le Borgne F, et al. Biochem Biophys Res Commun, 2011 Jun 17. PMID 21619872
    5. Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. Jogl G, et al. J Biol Chem, 2005 Jan 7. PMID 15492013

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. model of malonyl coA binding site by mutational analysis
      Title: Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-octanoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnitine O-octanoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carnitine O-octanoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-octanoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carnitine O-octanoyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carnitine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carnitine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carnitine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to norepinephrine stimulus HEP PubMed 
    involved_in coenzyme A metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in coenzyme A metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in coenzyme A metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in generation of precursor metabolites and energy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in generation of precursor metabolites and energy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in generation of precursor metabolites and energy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in long-chain fatty acid transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in medium-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in medium-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in medium-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in medium-chain fatty acid transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal carnitine O-octanoyltransferase
    Names
    COT
    NP_114193.2
    XP_006236066.1
    XP_006236067.1
    XP_038964382.2
    XP_038964386.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031987.2 → NP_114193.2  peroxisomal carnitine O-octanoyltransferase

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P11466, P48033
      UniProtKB/TrEMBL
      A6K232, F7F5D0, Q6GMN6
      Related
      ENSRNOP00000073847.3, ENSRNOT00000091799.3
      Conserved Domains (1) summary
      pfam00755
      Location:20 → 603
      Carn_acyltransf; Choline/Carnitine o-acyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      26031729..26088057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108454.2 → XP_038964382.2  peroxisomal carnitine O-octanoyltransferase isoform X2

      UniProtKB/Swiss-Prot
      P11466, P48033
      UniProtKB/TrEMBL
      A6K232, F7F5D0, Q6GMN6

    2. XM_039108458.2 → XP_038964386.1  peroxisomal carnitine O-octanoyltransferase isoform X2

      UniProtKB/Swiss-Prot
      P11466, P48033
      UniProtKB/TrEMBL
      A6K232, F7F5D0, Q6GMN6
      Conserved Domains (1) summary
      pfam00755
      Location:20 → 603
      Carn_acyltransf; Choline/Carnitine o-acyltransferase

    3. XM_006236004.5 → XP_006236066.1  peroxisomal carnitine O-octanoyltransferase isoform X1

      UniProtKB/Swiss-Prot
      P11466, P48033
      Related
      ENSRNOP00000071087.3, ENSRNOT00000090968.3
      Conserved Domains (1) summary
      pfam00755
      Location:73 → 656
      Carn_acyltransf; Choline/Carnitine o-acyltransferase

    4. XM_006236005.5 → XP_006236067.1  peroxisomal carnitine O-octanoyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006236067.1

      UniProtKB/Swiss-Prot
      P11466, P48033
      UniProtKB/TrEMBL
      A6K232, F7F5D0, Q6GMN6
      Conserved Domains (1) summary
      pfam00755
      Location:20 → 603
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11466.3 GenPept UniProtKB/Swiss-Prot:P11466

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