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    Morf4l2 mortality factor 4 like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317413, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Morf4l2provided by RGD
    Official Full Name
    mortality factor 4 like 2provided by RGD
    Primary source
    RGD:1359471
    See related
    EnsemblRapid:ENSRNOG00000002389 AllianceGenome:RGD:1359471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRG00119
    Summary
    Acts upstream of or within positive regulation of striated muscle cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus; nucleoplasm; and plasma membrane. Predicted to be part of NuA4 histone acetyltransferase complex and nucleosome. Orthologous to human MORF4L2 (mortality factor 4 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 2136.3), Brain (RPKM 908.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Morf4l2 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (104874850..104885946, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (100082562..100093658, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (107394468..107405564, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene acyl-protein thioesterase 1-like Neighboring gene transcription elongation factor A like 1 Neighboring gene uncharacterized LOC102555540 Neighboring gene glycine receptor alpha 4 Neighboring gene proteolipid protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. Tominaga K, et al. J Biol Chem, 2003 Dec 5. PMID 14506250
    2. Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation. Kee HJ, et al. J Biol Chem, 2007 Mar 9. PMID 17192267
    3. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417
    4. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93688, MGC94357

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of striated muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mortality factor 4-like protein 2
    Names
    MORF-related gene X protein
    liver regeneration-related protein LRRG00119
    transcription factor-like protein MRGX

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007714.2 → NP_001007715.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001007715.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q6QI89
      UniProtKB/TrEMBL
      A6KNT3
      Related
      ENSRNOP00000077798.1, ENSRNOT00000093840.2
      Conserved Domains (2) summary
      PLN02967
      Location:1 → 150
      PLN02967; kinase
      pfam05712
      Location:110 → 276
      MRG

    2. NM_001434138.1 → NP_001421067.1  mortality factor 4-like protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q6QI89
      UniProtKB/TrEMBL
      A6KNT3

    3. NM_001434139.1 → NP_001421068.1  mortality factor 4-like protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q6QI89
      UniProtKB/TrEMBL
      A6KNT3

    4. NM_001434140.1 → NP_001421069.1  mortality factor 4-like protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q6QI89
      UniProtKB/TrEMBL
      A6KNT3

    5. NM_001434141.1 → NP_001421070.1  mortality factor 4-like protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q6QI89
      UniProtKB/TrEMBL
      A6KNT3

    6. NM_001434142.1 → NP_001421071.1  mortality factor 4-like protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q6QI89
      UniProtKB/TrEMBL
      A6KNT3

    7. NM_001434143.1 → NP_001421072.1  mortality factor 4-like protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q6QI89
      UniProtKB/TrEMBL
      A6KNT3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      104874850..104885946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257296.5 → XP_006257358.1  mortality factor 4-like protein 2 isoform X1

      Conserved Domains (2) summary
      PLN02967
      Location:1 → 150
      PLN02967; kinase
      pfam05712
      Location:110 → 276
      MRG

    2. XM_039099802.2 → XP_038955730.1  mortality factor 4-like protein 2 isoform X1

      Conserved Domains (2) summary
      PLN02967
      Location:1 → 150
      PLN02967; kinase
      pfam05712
      Location:110 → 276
      MRG

    3. XM_006257295.4 → XP_006257357.1  mortality factor 4-like protein 2 isoform X1

      Related
      ENSRNOP00000081349.1, ENSRNOT00000108536.2
      Conserved Domains (2) summary
      PLN02967
      Location:1 → 150
      PLN02967; kinase
      pfam05712
      Location:110 → 276
      MRG

    4. XM_006257297.4 → XP_006257359.1  mortality factor 4-like protein 2 isoform X1

      Related
      ENSRNOP00000084568.1, ENSRNOT00000108398.2
      Conserved Domains (2) summary
      PLN02967
      Location:1 → 150
      PLN02967; kinase
      pfam05712
      Location:110 → 276
      MRG
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6QI89.1 GenPept UniProtKB/Swiss-Prot:Q6QI89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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