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    Mtln mitoregulin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 106631776, updated on 9-Dec-2024

    Summary

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    Symbol
    Mtlnprovided by RGD
    Full Name
    mitoregulinprovided by RGD
    Primary source
    RGD:10401149
    See related
    AllianceGenome:RGD:10401149
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Smim37
    Summary
    Predicted to be involved in several processes, including positive regulation of fatty acid beta-oxidation; positive regulation of mitochondrial membrane potential; and triglyceride homeostasis. Predicted to be located in mitochondrial inner membrane. Orthologous to human MTLN (mitoregulin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Mtln in Genome Data Viewer
    Location:
    3q36
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (135472081..135472939, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (115018810..115019668, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (120372665..120373523, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene mal, T-cell differentiation protein-like Neighboring gene nephrocystin 1 Neighboring gene WW domain containing adaptor with coiled-coil, pseudogene 2 Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase Neighboring gene acyl-CoA oxidase-like Neighboring gene Bcl2-like 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency. Stein CS, et al. Cell Rep, 2018 Jun 26. PMID 29949756, Free PMC Article
    2. Combining in silico prediction and ribosome profiling in a genome-wide search for novel putatively coding sORFs. Crappé J, et al. BMC Genomics, 2013 Sep 23. PMID 24059539, Free PMC Article
    3. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Xiao HS, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060780, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Other Names

    • small integral membrane protein 37

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of sequestering of calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of sequestering of calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in striated muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_132743.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      135472081..135472939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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