Sdhb succinate dehydrogenase complex iron sulfur subunit B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sdhbprovided by RGD
Official Full Name: succinate dehydrogenase complex iron sulfur subunit Bprovided by RGD
Primary source: RGD:1308598
See related: EnsemblRapid:ENSRNOG00000007967 AllianceGenome:RGD:1308598
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables succinate dehydrogenase (quinone) activity. Involved in respiratory electron transport chain and succinate metabolic process. Located in mitochondrial inner membrane. Biomarker of acute myocardial infarction. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 3044.7), Muscle (RPKM 1903.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (158547775..158568589)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (153264906..153285570)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (159484378..159505063)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Molecular and biochemical studies of succinate dehydrogenase in rat liver under conditions of alloxan diabetes].", trans "Molekuliarnye i biokhimicheskie issledovaniia suktsinatdegidrogenazy v pecheni krys v usloviiakh alloksanovogo diabeta.
Title: [Molecular and biochemical studies of succinate dehydrogenase in rat liver under conditions of alloxan diabetes].
Increased methylation of histone H3 is a general consequence of SDH loss-of-function in cultured mammalian cells.
Title: Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 2 iron, 2 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables 3 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 3 iron, 4 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables 3 iron, 4 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 4 iron, 4 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables 4 iron, 4 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase (quinone) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables succinate dehydrogenase (quinone) activity	ISO Inferred from Sequence Orthology more info
enables succinate dehydrogenase (quinone) activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquinone binding	ISO Inferred from Sequence Orthology more info
enables ubiquinone binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, succinate to ubiquinone	NAS Non-traceable Author Statement more info	PubMed
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed
involved_in respiratory electron transport chain	IBA Inferred from Biological aspect of Ancestor more info
involved_in respiratory electron transport chain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in succinate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex II (succinate dehydrogenase)	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex II (succinate dehydrogenase)	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex II (succinate dehydrogenase)	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Names: ip; iron-sulfur subunit of complex II; malate dehydrogenase [quinone] iron-sulfur subunit; succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

NP_001094009.1

EC 1.3.5.1

XP_063143542.1

EC 1.3.5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100539.1 → NP_001094009.1 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor

See identical proteins and their annotated locations for NP_001094009.1

Status: PROVISIONAL

Source sequence(s)

BC158620

UniProtKB/Swiss-Prot

B0BMZ2, P21913, Q0QEZ3

UniProtKB/TrEMBL

A0A8L2Q4P2

Related

ENSRNOP00000088032.2, ENSRNOT00000105563.2

Conserved Domains (1) summary

PLN00129
Location:29 → 273

PLN00129; succinate dehydrogenase [ubiquinone] iron-sulfur subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

158547775..158568589

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287472.1 → XP_063143542.1 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8L2Q4P2, A6ITQ1