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    TES testin LIM domain protein [ Homo sapiens (human) ]

    Gene ID: 26136, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TESprovided by HGNC
    Official Full Name
    testin LIM domain proteinprovided by HGNC
    Primary source
    HGNC:HGNC:14620
    See related
    Ensembl:ENSG00000135269 MIM:606085; AllianceGenome:HGNC:14620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TESS; TESS-2
    Summary
    Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a common fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Aug 2023]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 42.6), thyroid (RPKM 41.1) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TES in Genome Data Viewer
    Location:
    7q31.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (116210539..116258783)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (117525529..117573770)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (115850593..115898837)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724407 Neighboring gene VISTA enhancer hs1798 Neighboring gene transcription factor EC Neighboring gene Sharpr-MPRA regulatory region 6568 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:115807196-115807710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:115825203-115826194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:115826195-115827184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18555 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:115850475-115850737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26529 Neighboring gene uncharacterized LOC124901730 Neighboring gene uncharacterized LOC102724434 Neighboring gene uncharacterized LOC105375463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26531 Neighboring gene Sharpr-MPRA regulatory region 1934 Neighboring gene uncharacterized LOC124900233

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions. Sala S, et al. PLoS One, 2017. PMID 28542564, Free PMC Article
    2. RNAi knockdown of the focal adhesion protein TES reveals its role in actin stress fibre organisation. Griffith E, et al. Cell Motil Cytoskeleton, 2005 Mar. PMID 15662727
    3. Association of testis derived transcript gene variants and prostate cancer risk. Liu X, et al. J Urol, 2007 Mar. PMID 17296370
    4. LIM domain protein TES changes its conformational states in different cellular compartments. Zhong Y, et al. Mol Cell Biochem, 2009 Jan. PMID 18696217
    5. [Expression and clinical significance of TESTIN in primary gastric cancer]. Huang W, et al. Ai Zheng, 2008 Sep. PMID 18799041

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The value of lung function assessment and Testin expression detection in clinicopathological features and prognosis of NSCLC patients.
      Title: The value of lung function assessment and Testin expression detection in clinicopathological features and prognosis of NSCLC patients.
    2. Stress fiber strain recognition by the LIM protein testin is cryptic and mediated by RhoA.
      Title: Stress fiber strain recognition by the LIM protein testin is cryptic and mediated by RhoA.
    3. Chitinase 3-Like 1, Nestin, and Testin Proteins as Novel Biomarkers of Potential Clinical Use in Colorectal Cancer: A Review.
      Title: Chitinase 3-Like 1, Nestin, and Testin Proteins as Novel Biomarkers of Potential Clinical Use in Colorectal Cancer: A Review.
    4. Expression of testin is downregulated in the hearts of patients with dilated cardiomyopathy.
      Title: Testin protects against cardiac hypertrophy by targeting a calcineurin-dependent signalling pathway.
    5. TES-mediated upregulation of the transcription factor DDIT3 is involved in CFP suppression of breast cancer cell growth
      Title: CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3.
    6. These findings provide a better understanding of the development and progression of gastric cancer (GC) and indicate that TES may be used as a potential prognostic marker and therapeutic target for GC patients.
      Title: TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis.
    7. Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells.
      Title: Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells.
    8. validated two new TES cocomplex partners: TGFB1I1 and a short form of the glucocorticoid receptor. TES and TGFB1I1 are shown to oppositely affect cell spreading providing biological validity for their copresence in complexes since they act in similar processes
      Title: Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.
    9. these data indicate that TES functions as a necessary suppressor of colorectal cancer progression by activating p38-MAPK signaling pathways.
      Title: TES inhibits colorectal cancer progression through activation of p38.
    10. testin region (amino acids 52-233) harbouring the PET domain interacts with the C-terminal LIM1-2 domains
      Title: The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC1146, DKFZp586B2022

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    testin
    Names
    testis derived transcript (3 LIM domains)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015641.4 → NP_056456.1  testin isoform 1

      See identical proteins and their annotated locations for NP_056456.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform.
      Source sequence(s)
      AF245356, DC341259
      Consensus CDS
      CCDS5763.1
      UniProtKB/Swiss-Prot
      A4D0U6, Q9GZQ1, Q9HAJ9, Q9UGI8
      UniProtKB/TrEMBL
      A4D0U5, B2RDR4
      Related
      ENSP00000350937.4, ENST00000358204.9
      Conserved Domains (4) summary
      cd09413
      Location:236 → 293
      LIM1_Testin; The first LIM domain of Testin
      cd09416
      Location:299 → 354
      LIM2_Testin; The second LIM domain of Testin
      cd09419
      Location:361 → 419
      LIM3_Testin; The third LIM domain of Testin
      cd09829
      Location:109 → 196
      PET_testin; The PET domain of Testin

    2. NM_152829.3 → NP_690042.1  testin isoform 2

      See identical proteins and their annotated locations for NP_690042.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' UTR and uses a downstream start codon, compared to variant 1. Thus isoform 2 is nine amino acids shorter than isoform 1.
      Source sequence(s)
      AF245357, AK310995
      Consensus CDS
      CCDS5764.1
      UniProtKB/TrEMBL
      B2RDR4
      Related
      ENSP00000377121.2, ENST00000393481.6
      Conserved Domains (4) summary
      cd09413
      Location:227 → 284
      LIM1_Testin; The first LIM domain of Testin
      cd09416
      Location:290 → 345
      LIM2_Testin; The second LIM domain of Testin
      cd09419
      Location:352 → 410
      LIM3_Testin; The third LIM domain of Testin
      cd09829
      Location:100 → 187
      PET_testin; The PET domain of Testin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      116210539..116258783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      117525529..117573770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UGI8.1 GenPept UniProtKB/Swiss-Prot:Q9UGI8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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