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    ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 [ Homo sapiens (human) ]

    Gene ID: 7903, updated on 9-Dec-2024

    Summary

    Official Symbol
    ST8SIA4provided by HGNC
    Official Full Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4provided by HGNC
    Primary source
    HGNC:HGNC:10871
    See related
    Ensembl:ENSG00000113532 MIM:602547; AllianceGenome:HGNC:10871
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PST; PST1; SIAT8D; SIAT8-D; ST8SiaIV; ST8SIA-IV
    Summary
    The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 6.6), lymph node (RPKM 4.8) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ST8SIA4 in Genome Data Viewer
    Location:
    5q21.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (100806933..100903282, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (101315265..101411539, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (100142637..100238986, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22843 Neighboring gene family with sequence similarity 174 member A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16206 Neighboring gene MPRA-validated peak5372 silencer Neighboring gene MPRA-validated peak5373 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:100058179-100058822 Neighboring gene RN7SK pseudogene 62 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:100112471-100113670 Neighboring gene NANOG hESC enhancer GRCh37_chr5:100121674-100122204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22848 Neighboring gene microRNA 548p Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:100236435-100236936 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:100238074-100238643 Neighboring gene uncharacterized LOC107986437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:100516072-100516644 Neighboring gene uncharacterized LOC107986438 Neighboring gene general transcription factor IIIA pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that ST8SIA4 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with ST8SIA4 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC34450, MGC61459

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in N-glycan processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ganglioside biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oligosaccharide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein glycosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sialylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
    Names
    CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase
    ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 4
    alpha-2,8-sialyltransferase 8D
    polysialyltransferase
    polysialyltransferase-1
    sialyltransferase 8 (alpha-2, 8-polysialytransferase) D
    sialyltransferase 8D
    sialyltransferase St8Sia IV
    sialytransferase St8Sia IV
    NP_005659.1
    NP_778222.1
    XP_005272135.1
    XP_011541932.1
    XP_054209412.1
    XP_054209413.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005668.6NP_005659.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform a precursor

      See identical proteins and their annotated locations for NP_005659.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AA836260, AC117530, AK292872, DA862968
      Consensus CDS
      CCDS4091.1
      UniProtKB/Swiss-Prot
      A8KA07, G3V104, Q8N1F4, Q92187, Q92693
      Related
      ENSP00000231461.4, ENST00000231461.10
      Conserved Domains (1) summary
      pfam00777
      Location:94353
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    2. NM_175052.3NP_778222.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform b precursor

      See identical proteins and their annotated locations for NP_778222.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons and its transcription extends past a splice site that is used in variant 1, resulting in a shorter 3' coding region and a novel 3' UTR compared to variant 1. It encodes isoform b which is truncated at the C-terminus, compared to isoform a.
      Source sequence(s)
      BC027866, DA862968
      Consensus CDS
      CCDS47252.1
      UniProtKB/Swiss-Prot
      Q92187
      Related
      ENSP00000428914.1, ENST00000451528.2
      Conserved Domains (1) summary
      pfam00777
      Location:94168
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      100806933..100903282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543630.3XP_011541932.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform X2

      Conserved Domains (1) summary
      pfam00777
      Location:94255
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    2. XM_005272078.4XP_005272135.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform X1

      Conserved Domains (1) summary
      pfam00777
      Location:94262
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      101315265..101411539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353438.1XP_054209413.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform X2

    2. XM_054353437.1XP_054209412.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform X1