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    FZD1 frizzled class receptor 1 [ Homo sapiens (human) ]

    Gene ID: 8321, updated on 27-Nov-2024

    Summary

    Official Symbol
    FZD1provided by HGNC
    Official Full Name
    frizzled class receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:4038
    See related
    Ensembl:ENSG00000157240 MIM:603408; AllianceGenome:HGNC:4038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
    Orthologs
    NEW
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    Genomic context

    See FZD1 in Genome Data Viewer
    Location:
    7q21.13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (91264433..91271326)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (92512278..92519169)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (90893748..90900641)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 14 Neighboring gene uncharacterized LOC124901694 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:90661021-90661555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:90690954-90691454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:90691455-90691955 Neighboring gene VISTA enhancer hs1627 Neighboring gene VISTA enhancer hs1628 Neighboring gene VISTA enhancer hs1633 Neighboring gene PTP4A1 pseudogene 3 Neighboring gene VISTA enhancer hs1631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18363 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18364 Neighboring gene uncharacterized LOC124901695 Neighboring gene heart enhancer 20 Neighboring gene long intergenic non-protein coding RNA 2932 Neighboring gene NIPA2 pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association scan of dental caries in the permanent dentition.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The expression of frizzled class receptor 1 (FZD1) gene is upregulated in both Jurkat-Tat101 and Jurkat-Tat72 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ95923, DKFZp564G072

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Wnt receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables Wnt receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Wnt-protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables frizzled binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in astrocyte-dopaminergic neuron signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autocrine signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endothelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hard palate development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membranous septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in midbrain dopaminergic neuron differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in muscular septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in presynapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of mesenchymal stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of presynapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Wnt signalosome IC
    Inferred by Curator
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    frizzled-1
    Names
    Wnt receptor
    frizzled 1, seven transmembrane spanning receptor
    frizzled family receptor 1
    frizzled homolog 1
    frizzled, Drosophila, homolog of, 1
    fz-1
    fzE1
    hFz1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003505.2NP_003496.1  frizzled-1

      See identical proteins and their annotated locations for NP_003496.1

      Status: REVIEWED

      Source sequence(s)
      AB017363, AC084381
      Consensus CDS
      CCDS5620.1
      UniProtKB/Swiss-Prot
      A4D1E8, O94815, Q549T8, Q9UP38
      UniProtKB/TrEMBL
      B2RC95
      Related
      ENSP00000287934.2, ENST00000287934.4
      Conserved Domains (2) summary
      cd07465
      Location:112238
      CRD_FZ1; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 1 (Fz1) receptor
      pfam01534
      Location:310634
      Frizzled; Frizzled/Smoothened family membrane region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      91264433..91271326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      92512278..92519169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)