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    EEIG2 EEIG family member 2 [ Homo sapiens (human) ]

    Gene ID: 284611, updated on 27-Nov-2024

    Summary

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    Official Symbol
    EEIG2provided by HGNC
    Official Full Name
    EEIG family member 2provided by HGNC
    Primary source
    HGNC:HGNC:27637
    See related
    Ensembl:ENSG00000162636 AllianceGenome:HGNC:27637
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SYM-3B; FAM102B
    Expression
    Ubiquitous expression in brain (RPKM 11.6), gall bladder (RPKM 11.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EEIG2 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (108560100..108639322)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (108593088..108672314)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (109102722..109181944)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:109045678-109046211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1134 Neighboring gene ST13, Hsp70 interacting protein pseudogene 21 Neighboring gene RPL7L1 pseudogene 21 Neighboring gene NANOG hESC enhancer GRCh37_chr1:109060171-109060846 Neighboring gene CRISPRi-validated cis-regulatory element chr1.7484 Neighboring gene Sharpr-MPRA regulatory region 3357 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1424 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:109111447-109111662 Neighboring gene MPRA-validated peak351 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109203434-109204023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109204024-109204612 Neighboring gene HEN methyltransferase 1 Neighboring gene uncharacterized LOC105378890

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
    2. Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. Huber FM, et al. Proc Natl Acad Sci U S A, 2017 Jun 6. PMID 28533407, Free PMC Article
    3. RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. Guderian G, et al. J Biol Chem, 2011 Jan 21. PMID 21081503, Free PMC Article
    4. SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk. Lukinović V, et al. Cancer Discov, 2022 Sep 2. PMID 35819319, Free PMC Article
    5. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp779B126, DKFZp686N01110

    General protein information

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    Preferred Names
    EEIG family member 2
    Names
    family with sequence similarity 102 member B
    protein FAM102B
    sym-3 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010883.3 → NP_001010883.2  EEIG family member 2

      See identical proteins and their annotated locations for NP_001010883.2

      Status: VALIDATED

      Source sequence(s)
      AL160171
      Consensus CDS
      CCDS30786.2
      UniProtKB/Swiss-Prot
      A1L1A1, B0QZ46, B0QZ47, Q5T8I3, Q68DH7
      Related
      ENSP00000359052.3, ENST00000370035.8
      Conserved Domains (1) summary
      pfam10358
      Location:9 → 149
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      108560100..108639322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      108593088..108672314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T8I3.2 GenPept UniProtKB/Swiss-Prot:Q5T8I3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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