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    SAE1B SUMO-activating enzyme 1B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835127, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAE1B
    Official Full Name
    SUMO-activating enzyme 1B
    Primary source
    TAIR:AT5G50580
    Locus tag
    AT5G50580
    See related
    Araport:AT5G50580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT-SAE1-2; MBA10.22; MBA10_22; SUMO-activating enzyme 1B
    Summary
    Encodes one of the two subunits of the SUMO activation enzyme required during sumolation. Sumolation is a post-translational protein modification process similar to ubiquitination during which a polypeptide (SUMO) is covalently attached to a target protein.
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    Genomic context

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    See SAE1B in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (20585349..20587761)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Squamosa promoter-binding protein-like (SBP domain) transcription factor family protein Neighboring gene hydroxysteroid dehydrogenase 4 Neighboring gene hydroxysteroid dehydrogenase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diversification of SUMO-activating enzyme in Arabidopsis: implications in SUMO conjugation. Castaño-Miquel L, et al. Mol Plant, 2013 Sep. PMID 23482370
    2. The small ubiquitin-like modifier (SUMO) protein modification system in Arabidopsis. Accumulation of SUMO1 and -2 conjugates is increased by stress. Kurepa J, et al. J Biol Chem, 2003 Feb 28. PMID 12482876
    3. The PHD domain of plant PIAS proteins mediates sumoylation of bromodomain GTE proteins. Garcia-Dominguez M, et al. J Biol Chem, 2008 Aug 1. PMID 18502747
    4. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124436.4
    NM_180831.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables SUMO activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SUMO activating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SUMO-activating enzyme 1B
    NP_568732.2
    • SUMO-activating enzyme 1B (SAE1B); CONTAINS InterPro DOMAIN/s: UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040), Ubiquitin-activating enzyme, E1-like (InterPro:IPR000011); BEST Arabidopsis thaliana protein match is: SUMO activating enzyme 1B (TAIR:AT5G50680.1); Has 4919 Blast hits to 4279 proteins in 1113 species: Archae - 94; Bacteria - 1852; Metazoa - 1152; Fungi - 654; Plants - 410; Viruses - 0; Other Eukaryotes - 757 (source: NCBI BLink).
    NP_851162.1
    • SUMO-activating enzyme 1B (SAE1B); CONTAINS InterPro DOMAIN/s: Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: SUMO activating enzyme 1B (TAIR:AT5G50680.2); Has 4947 Blast hits to 4294 proteins in 1121 species: Archae - 94; Bacteria - 1869; Metazoa - 1154; Fungi - 667; Plants - 410; Viruses - 0; Other Eukaryotes - 753 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20585349..20587761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124436.4 → NP_568732.2  SUMO-activating enzyme 1B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568732.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0DI12, P0DI13, Q8LCB9, Q8LKN3, Q9LUF3
      UniProtKB/TrEMBL
      A0A654G9R2
      Conserved Domains (1) summary
      cd01492
      Location:11 → 314
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

    2. NM_180831.2 → NP_851162.1  SUMO-activating enzyme 1B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851162.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654G9R2
      Conserved Domains (2) summary
      cd01492
      Location:11 → 312
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:14 → 304
      ThiF; ThiF family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DI12.1
    P0DI13.1

    Gene LinkOut

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