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    FBXO3 F-box protein 3 [ Homo sapiens (human) ]

    Gene ID: 26273, updated on 27-Nov-2024

    Summary

    Official Symbol
    FBXO3provided by HGNC
    Official Full Name
    F-box protein 3provided by HGNC
    Primary source
    HGNC:HGNC:13582
    See related
    Ensembl:ENSG00000110429 MIM:609089; AllianceGenome:HGNC:13582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBA; FBX3
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 11.3), kidney (RPKM 10.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FBXO3 in Genome Data Viewer
    Location:
    11p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (33740944..33774520, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (33877954..33911529, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (33762490..33796066, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene KIAA1549 like Neighboring gene uncharacterized LOC105376617 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:33676703-33677902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4582 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:33711673-33712872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3240 Neighboring gene chromosome 11 open reading frame 91 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3241 Neighboring gene CD59 molecule (CD59 blood group) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4585 Neighboring gene Sharpr-MPRA regulatory region 12829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:33795080-33795580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3243 Neighboring gene FBXO3 divergent transcript Neighboring gene Spi-C transcription factor pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetics of coronary artery calcification among African Americans, a meta-analysis.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat is identified to have a physical interaction with F-box protein 3 (FBXO3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp564B092

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    F-box only protein 3
    Names
    F-box protein FBX3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012175.4NP_036307.2  F-box only protein 3 isoform 1

      See identical proteins and their annotated locations for NP_036307.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1) which includes a highly acidic D/E-rich domain and two poly-R pieces at the C-terminus.
      Source sequence(s)
      BC039291, BC046110
      Consensus CDS
      CCDS7887.1
      UniProtKB/Swiss-Prot
      B3KY16, D3DR05, Q86X90, Q9H0V2, Q9NUX2, Q9UK99
      UniProtKB/TrEMBL
      Q59GS0
      Related
      ENSP00000265651.3, ENST00000265651.8
      Conserved Domains (3) summary
      pfam04379
      Location:294383
      DUF525; ApaG domain
      pfam09346
      Location:121249
      SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)
      pfam12937
      Location:1357
      F-box-like
    2. NM_033406.4NP_208385.1  F-box only protein 3 isoform 2

      See identical proteins and their annotated locations for NP_208385.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is divergent from variant 1 at the 3' terminus. It encodes a C-terminal truncated isoform, which lacks the D/E-rich domain and poly-Rs, as compared to isoform 1.
      Source sequence(s)
      AC113192, AF176702, AL049629, BC017107, BC039291
      Consensus CDS
      CCDS44566.1
      UniProtKB/TrEMBL
      Q59GS0
      Related
      ENSP00000408836.2, ENST00000448981.6
      Conserved Domains (3) summary
      smart00860
      Location:121249
      SMI1_KNR4; SMI1 / KNR4 family
      pfam12937
      Location:1357
      F-box-like; F-box-like
      cl01119
      Location:279404
      DUF525; ApaG domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      33740944..33774520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519980.2XP_011518282.1  F-box only protein 3 isoform X1

      Conserved Domains (3) summary
      pfam04379
      Location:294383
      DUF525; Protein of unknown function (DUF525)
      pfam09346
      Location:121249
      SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)
      pfam12937
      Location:1357
      F-box-like; F-box-like
    2. XM_047426752.1XP_047282708.1  F-box only protein 3 isoform X3

    3. XM_011519981.3XP_011518283.1  F-box only protein 3 isoform X2

      See identical proteins and their annotated locations for XP_011518283.1

      UniProtKB/TrEMBL
      Q59GS0
      Related
      ENSP00000431745.1, ENST00000534136.5
      Conserved Domains (3) summary
      pfam04379
      Location:294383
      DUF525; ApaG domain
      pfam09346
      Location:121249
      SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)
      pfam12937
      Location:1357
      F-box-like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      33877954..33911529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368394.1XP_054224369.1  F-box only protein 3 isoform X1

    2. XM_054368396.1XP_054224371.1  F-box only protein 3 isoform X3

    3. XM_054368395.1XP_054224370.1  F-box only protein 3 isoform X2