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    Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831958, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi
    Primary source
    TAIR:AT5G18400
    Locus tag
    AT5G18400
    See related
    Araport:AT5G18400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtDRE2; DRE2; F20L16.120; F20L16_120; homolog of yeast DRE2
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (6092682..6095080, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S5 domain 2-like superfamily protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Putative membrane lipoprotein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epigenetic role for the conserved Fe-S cluster biogenesis protein AtDRE2 in Arabidopsis thaliana. Buzas DM, et al. Proc Natl Acad Sci U S A, 2014 Sep 16. PMID 25197096, Free PMC Article
    2. Requirements of the cytosolic iron-sulfur cluster assembly pathway in Arabidopsis. Bernard DG, et al. Philos Trans R Soc Lond B Biol Sci, 2013 Jul 19. PMID 23754812, Free PMC Article
    3. Expression of a dominant-negative AtNEET-H89C protein disrupts iron-sulfur metabolism and iron homeostasis in Arabidopsis. Zandalinas SI, et al. Plant J, 2020 Mar. PMID 31642128
    4. NBP35 interacts with DRE2 in the maturation of cytosolic iron-sulphur proteins in Arabidopsis thaliana. Bastow EL, et al. Plant J, 2017 Feb. PMID 27801963, Free PMC Article
    5. ATR3 encodes a diflavin reductase essential for Arabidopsis embryo development. Varadarajan J, et al. New Phytol, 2010 Jul. PMID 20406405

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of a dominant-negative AtNEET-H89C protein disrupts iron-sulfur metabolism and iron homeostasis in Arabidopsis.
      Title: Expression of a dominant-negative AtNEET-H89C protein disrupts iron-sulfur metabolism and iron homeostasis in Arabidopsis.
    2. Data indicate that NBP35 physically interacts with DRE2.
      Title: NBP35 interacts with DRE2 in the maturation of cytosolic iron-sulphur proteins in Arabidopsis thaliana.
    3. Results implicate AtDRE2 in DNA methylation control related to maternal activation in the EDL, an epigenetic function hitherto unrecognized for this protein in any organism. [AtDRE2]
      Title: Epigenetic role for the conserved Fe-S cluster biogenesis protein AtDRE2 in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001085133.2
    NM_121845.3
    NM_180513.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi
    NP_001078602.1
    • Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF689 (InterPro:IPR007785); BEST Arabidopsis thaliana protein match is: Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis (TAIR:AT5G18362.1); Has 539 Blast hits to 538 proteins in 227 species: Archae - 0; Bacteria - 0; Metazoa - 183; Fungi - 185; Plants - 75; Viruses - 0; Other Eukaryotes - 96 (source: NCBI BLink).
    NP_568363.1
    • Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF689 (InterPro:IPR007785); BEST Arabidopsis thaliana protein match is: Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis (TAIR:AT5G18362.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_850844.1
    • Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF689 (InterPro:IPR007785); BEST Arabidopsis thaliana protein match is: Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis (TAIR:AT5G18362.1); Has 540 Blast hits to 539 proteins in 227 species: Archae - 0; Bacteria - 0; Metazoa - 183; Fungi - 186; Plants - 75; Viruses - 0; Other Eukaryotes - 96 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6092682..6095080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121845.3 → NP_568363.1  Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JWM7, Q8L7Z3, Q8L9M1, Q8RXJ2
      UniProtKB/TrEMBL
      A0A178U7U0, A0A5S9Y586
      Conserved Domains (1) summary
      pfam05093
      Location:198 → 263
      CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

    2. NM_180513.1 → NP_850844.1  Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850844.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178U7U0, A0A654G2K6
      Conserved Domains (1) summary
      pfam05093
      Location:195 → 260
      CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

    3. NM_001085133.2 → NP_001078602.1  Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078602.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JWM7, Q8L7Z3, Q8L9M1, Q8RXJ2
      UniProtKB/TrEMBL
      A0A178U7U0, A0A5S9Y586
      Conserved Domains (1) summary
      pfam05093
      Location:198 → 263
      CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L7Z3.1

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