FHL1 four and a half LIM domains 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FHL1provided by HGNC
Official Full Name: four and a half LIM domains 1provided by HGNC
Primary source: HGNC:HGNC:3702
See related: Ensembl:ENSG00000022267 MIM:300163; AllianceGenome:HGNC:3702
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KYOT; SLIM; FCMSU; FHL-1; FHL1A; FHL1B; FLH1A; SLIM1; XMPMA; RBMX1A; RBMX1B; SLIM-1; SLIMMER
Summary: This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]
Expression: Broad expression in heart (RPKM 286.6), fat (RPKM 281.6) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq26.3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (136146702..136211359)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (134455091..134519750)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (135228861..135293518)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FHL1: A novel diagnostic marker for papillary thyroid carcinoma.
Title: FHL1: A novel diagnostic marker for papillary thyroid carcinoma.
Low FHL1 expression indicates a good prognosis and drug sensitivity in ovarian cancer.
Title: Low FHL1 expression indicates a good prognosis and drug sensitivity in ovarian cancer.
Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.
Title: Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.
Identification of novel FHL1 mutations associated with X-linked scapuloperoneal myopathy in unrelated Chinese patients.
Title: Identification of novel FHL1 mutations associated with X-linked scapuloperoneal myopathy in unrelated Chinese patients.
Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells.
Title: Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells.
FHL1 as a novel prognostic biomarker and correlation with immune infiltration levels in lung adenocarcinoma.
Title: FHL1 as a novel prognostic biomarker and correlation with immune infiltration levels in lung adenocarcinoma.
Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells.
Title: Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells.
MiR-96-5p Facilitates Lung Adenocarcinoma Cell Phenotypes by Inhibiting FHL1.
Title: MiR-96-5p Facilitates Lung Adenocarcinoma Cell Phenotypes by Inhibiting FHL1.
Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation.
Title: Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation.
Three novel FHL1 variants cause a mild phenotype of Emery-Dreifuss muscular dystrophy.
Title: Three novel FHL1 variants cause a mild phenotype of Emery-Dreifuss muscular dystrophy.

Submit: New GeneRIF Correction See all GeneRIFs (84)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Myopathy, reducing body, X-linked, childhood-onset MedGen: C4225159 OMIM: 300718 GeneReviews: Not available	not available
Myopathy, reducing body, X-linked, early-onset, severe MedGen: C4225423 OMIM: 300717 GeneReviews: Not available	not available
Uruguay Faciocardiomusculoskeletal syndrome MedGen: C1846010 OMIM: 300280 GeneReviews: Not available	not available
X-linked myopathy with postural muscle atrophy MedGen: C2678055 OMIM: 300696 GeneReviews: Emery-Dreifuss Muscular Dystrophy	not available
X-linked scapuloperoneal muscular dystrophy MedGen: C2678061 OMIM: 300695 GeneReviews: Not available	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3S2774E (e-PCR)
- UniSTS:150815

WI-18109 (e-PCR)
- UniSTS:4408

AL032580 (e-PCR)
- UniSTS:93253

G27965 (e-PCR)
- UniSTS:598

FHL1_1806 (e-PCR)
- UniSTS:280672

DXS1322 (e-PCR)
- UniSTS:99188

A008Y44 (e-PCR)
- UniSTS:28304

RH35898 (e-PCR)
- UniSTS:39832

G65664 (e-PCR)
- UniSTS:225455

SHGC-31168 (e-PCR)
- UniSTS:22710

SHGC-77523 (e-PCR)
- UniSTS:22711

DXS6971E (e-PCR)
- UniSTS:71888

DXS7158 (e-PCR)
- UniSTS:27615

DXS7575 (e-PCR)
- UniSTS:154109

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in muscle organ development	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane depolarization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of potassium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in focal adhesion	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: four and a half LIM domains protein 1

Names: LIM protein SLIMMER; four-and-a-half Lin11, Isl-1 and Mec-3 domains 1; skeletal muscle LIM-protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015895.1 RefSeqGene

Range

5134..68955

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_739

mRNA and Protein(s)

NM_001159699.2 → NP_001153171.1 four and a half LIM domains protein 1 isoform 5

See identical proteins and their annotated locations for NP_001153171.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, 3' UTR, and 3' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 5) has distinct N- and C-termini and is shorter than isoform 1.

Source sequence(s)

BC088369, BM995585, DC373386

Consensus CDS

CCDS55506.1

UniProtKB/TrEMBL

Q53FI7

Related

ENSP00000359717.1, ENST00000370683.6

Conserved Domains (5) summary

cd09344
Location:56 → 109

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:233 → 296

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:117 → 174

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:178 → 230

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:21 → 49

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001159700.2 → NP_001153172.1 four and a half LIM domains protein 1 isoform 2

See identical proteins and their annotated locations for NP_001153172.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).

Source sequence(s)

AK304680, AL078638, BC088369, BM995585, DC363191

Consensus CDS

CCDS14655.1

UniProtKB/TrEMBL

Q53FI7

Related

ENSP00000485897.1, ENST00000630084.2

Conserved Domains (5) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001159701.2 → NP_001153173.1 four and a half LIM domains protein 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001153173.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR, and coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 3) is shorter and has distinct N- and C-termini, compared to isoform 1.

Source sequence(s)

AK301642, BC010998, BM995585

Consensus CDS

CCDS55505.1

UniProtKB/TrEMBL

Q53FI7

Related

ENSP00000437673.1, ENST00000539015.5

Conserved Domains (5) summary

cd09344
Location:69 → 122

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:246 → 309

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:130 → 187

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:191 → 243

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:34 → 62

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001159702.3 → NP_001153174.1 four and a half LIM domains protein 1 isoform 1

See identical proteins and their annotated locations for NP_001153174.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest protein (isoform 1).

Source sequence(s)

AF063002, AF098518, BC010998, BM995585

Consensus CDS

CCDS55507.1

UniProtKB/Swiss-Prot

B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

Related

ENSP00000377710.2, ENST00000394155.8

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001159703.2 → NP_001153175.1 four and a half LIM domains protein 1 isoform 4

See identical proteins and their annotated locations for NP_001153175.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding region, compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1.

Source sequence(s)

AF220153, AK301642, AL078638, BC010998, BE965488, BM995585, DA497183

Consensus CDS

CCDS76036.1

UniProtKB/TrEMBL

A0A0D9SFZ9

Related

ENSP00000477609.1, ENST00000618438.4

Conserved Domains (3) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001159704.1 → NP_001153176.1 four and a half LIM domains protein 1 isoform 2

See identical proteins and their annotated locations for NP_001153176.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).

Source sequence(s)

AK122708, AL078638, BM995585

Consensus CDS

CCDS14655.1

UniProtKB/TrEMBL

Q53FI7

Related

ENSP00000443333.1, ENST00000543669.5

Conserved Domains (5) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001167819.1 → NP_001161291.1 four and a half LIM domains protein 1 isoform 2

See identical proteins and their annotated locations for NP_001161291.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) uses a different segment for its 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).

Source sequence(s)

BC010998, BM995585, DA917361, DA982372

Consensus CDS

CCDS14655.1

UniProtKB/TrEMBL

Q53FI7

Related

ENSP00000377709.2, ENST00000394153.6

Conserved Domains (5) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001330659.2 → NP_001317588.1 four and a half LIM domains protein 1 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (10) uses an alternate 5'-terminal exon, lacks two in-frame exons in the 3' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AL078638

Consensus CDS

CCDS83493.1

UniProtKB/TrEMBL

A0A0D9SFZ9, Q5JXI2

Related

ENSP00000359710.3, ENST00000370676.7

Conserved Domains (3) summary

cd09344
Location:56 → 109

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:117 → 174

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:21 → 49

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001369326.1 → NP_001356255.1 four and a half LIM domains protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AL078638

Consensus CDS

CCDS55507.1

UniProtKB/Swiss-Prot

B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

Related

ENSP00000498684.1, ENST00000651089.1

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001369327.2 → NP_001356256.1 four and a half LIM domains protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AL078638

Consensus CDS

CCDS55507.1

UniProtKB/Swiss-Prot

B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001369328.1 → NP_001356257.1 four and a half LIM domains protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AL078638

Consensus CDS

CCDS55507.1

UniProtKB/Swiss-Prot

B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001369329.1 → NP_001356258.1 four and a half LIM domains protein 1 isoform 2

Status: REVIEWED

Source sequence(s)

AL078638

Consensus CDS

CCDS14655.1

UniProtKB/TrEMBL

Q53FI7

Conserved Domains (5) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001369330.1 → NP_001356259.1 four and a half LIM domains protein 1 isoform 2

Status: REVIEWED

Source sequence(s)

AL078638

Consensus CDS

CCDS14655.1

UniProtKB/TrEMBL

Q53FI7

Related

ENSP00000444815.1, ENST00000535737.5

Conserved Domains (5) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001369331.1 → NP_001356260.1 four and a half LIM domains protein 1 isoform 2

Status: REVIEWED

Source sequence(s)

AL078638

Consensus CDS

CCDS14655.1

UniProtKB/TrEMBL

Q53FI7

Related

ENSP00000359708.1, ENST00000370674.3

Conserved Domains (5) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001449.5 → NP_001440.2 four and a half LIM domains protein 1 isoform 2

See identical proteins and their annotated locations for NP_001440.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).

Source sequence(s)

BC010998, BM995585

Consensus CDS

CCDS14655.1

UniProtKB/TrEMBL

Q53FI7

Related

ENSP00000499016.1, ENST00000651929.2

Conserved Domains (5) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RNA

NR_027621.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (8) includes an additional exon at the 5' end, compared to variant 1. This variant is represented as non-coding because it contains an upstream ORF that is predicted to interfere with translation of the downstream expected ORF as used in variant 1.

Source sequence(s)

AK289411, AL078638, BC010998, BM995585

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

136146702..136211359

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047441926.1 → XP_047297882.1 four and a half LIM domains protein 1 isoform X2

UniProtKB/Swiss-Prot

B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
XM_047441927.1 → XP_047297883.1 four and a half LIM domains protein 1 isoform X3
XM_024452354.2 → XP_024308122.1 four and a half LIM domains protein 1 isoform X2

UniProtKB/Swiss-Prot

B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_047441925.1 → XP_047297881.1 four and a half LIM domains protein 1 isoform X2

UniProtKB/Swiss-Prot

B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
XM_006724743.3 → XP_006724806.1 four and a half LIM domains protein 1 isoform X1

See identical proteins and their annotated locations for XP_006724806.1

Conserved Domains (4) summary

cd09344
Location:56 → 109

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:117 → 174

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:178 → 230

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:21 → 49

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006724746.4 → XP_006724809.1 four and a half LIM domains protein 1 isoform X2

See identical proteins and their annotated locations for XP_006724809.1

UniProtKB/Swiss-Prot

B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers