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    CINV1 cytosolic invertase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840454, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CINV1
    Official Full Name
    cytosolic invertase 1
    Primary source
    TAIR:AT1G35580
    Locus tag
    AT1G35580
    See related
    Araport:AT1G35580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    A/N-InvG; alkaline/neutral invertase G; cytosolic invertase 1; F15O4.33
    Summary
    CINV1 / A/N-InvG is an alkaline/neutral invertase that breaks sucrose down into fructose and glucose (GH100). The exact localization of CINV1 remains under investigation but there is evidence that fluorescently-tagged CINV1 localizes to the cytoplasm. atinvg mutants have reduced root growth, reduced invertase activity, and increased expression of antioxidant genes under basal conditions. The levels of CINV1 / A/N-InvG transcripts rise in response to a hydrogen peroxide treatment. The protein has been shown to interact with PIP5K9.
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    Genomic context

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    See CINV1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (13122082..13125328, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene TCP family transcription factor Neighboring gene pseudo Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of Arabidopsis thaliana neutral invertase 2. Tarkowski ŁP, et al. Acta Crystallogr F Struct Biol Commun, 2020 Mar 1. PMID 32134001, Free PMC Article
    2. AtCYT-INV1, a neutral invertase, is involved in osmotic stress-induced inhibition on lateral root growth in Arabidopsis. Qi X, et al. Plant Mol Biol, 2007 Jul. PMID 17508130
    3. Structural insights into the pH-controlled targeting of plant cell-wall invertase by a specific inhibitor protein. Hothorn M, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20858733, Free PMC Article
    4. PIP5K9, an Arabidopsis phosphatidylinositol monophosphate kinase, interacts with a cytosolic invertase to negatively regulate sugar-mediated root growth. Lou Y, et al. Plant Cell, 2007 Jan. PMID 17220200, Free PMC Article
    5. Exploring the neutral invertase-oxidative stress defence connection in Arabidopsis thaliana. Xiang L, et al. J Exp Bot, 2011 Jul. PMID 21441406, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CINV1 directly interacts with 14-3-3 proteins at phosphorylated Ser547.Light modulated activity of CINV1 involves the interaction with 14-3-3 proteins.
      Title: Light modulated activity of root alkaline/neutral invertase involves the interaction with 14-3-3 proteins.
    2. Data present the 2.6 A crystal structure of Arabidopsis cell-wall invertase 1 (INV1) in complex with a protein inhibitor (CIF, or cell-wall inhibitor of beta-fructosidase) from tobacco.
      Title: Structural insights into the pH-controlled targeting of plant cell-wall invertase by a specific inhibitor protein.
    3. PIP5K9 interacts with CINV1 (At1g35580) to negatively regulate sugar-mediated root cell elongation.
      Title: PIP5K9, an Arabidopsis phosphatidylinositol monophosphate kinase, interacts with a cytosolic invertase to negatively regulate sugar-mediated root growth.
    4. A neutral invertase gene, AtCYT-INV1, plays multiple roles in plant development and is involved in osmotic stress-induced inhibition on lateral root growth by controlling the concentration of hexose in cells. [AtCYT-INV1]
      Title: AtCYT-INV1, a neutral invertase, is involved in osmotic stress-induced inhibition on lateral root growth in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036066.2
    NM_103255.2
    NM_179419.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables beta-fructofuranosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-fructofuranosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endo-alpha-N-acetylgalactosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sucrose alpha-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within amino acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein hexamerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sucrose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytosolic invertase 1
    NP_001031143.1
    • cytosolic invertase 1 (CINV1); FUNCTIONS IN: protein binding, beta-fructofuranosidase activity; INVOLVED IN: carbohydrate metabolic process, sucrose catabolic process, using invertase or sucrose synthase, root development, cellular amino acid metabolic process; LOCATED IN: cytosol, nucleus, plasma membrane, membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Plant neutral invertase (InterPro:IPR006937), Six-hairpin glycosidase-like (InterPro:IPR008928); BEST Arabidopsis thaliana protein match is: cytosolic invertase 2 (TAIR:AT4G09510.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_174791.2
    • cytosolic invertase 1 (CINV1); FUNCTIONS IN: protein binding, beta-fructofuranosidase activity; INVOLVED IN: carbohydrate metabolic process, sucrose catabolic process, using invertase or sucrose synthase, root development, cellular amino acid metabolic process; LOCATED IN: cytosol, nucleus, plasma membrane, membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Plant neutral invertase (InterPro:IPR006937), Six-hairpin glycosidase-like (InterPro:IPR008928); BEST Arabidopsis thaliana protein match is: cytosolic invertase 2 (TAIR:AT4G09510.1); Has 684 Blast hits to 681 proteins in 93 species: Archae - 0; Bacteria - 123; Metazoa - 0; Fungi - 0; Plants - 317; Viruses - 0; Other Eukaryotes - 244 (source: NCBI BLink).
    NP_849750.1
    • cytosolic invertase 1 (CINV1); FUNCTIONS IN: protein binding, beta-fructofuranosidase activity; INVOLVED IN: carbohydrate metabolic process, sucrose catabolic process, using invertase or sucrose synthase, root development, cellular amino acid metabolic process; LOCATED IN: cytosol, nucleus, plasma membrane, membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Plant neutral invertase (InterPro:IPR006937), Six-hairpin glycosidase-like (InterPro:IPR008928); BEST Arabidopsis thaliana protein match is: cytosolic invertase 2 (TAIR:AT4G09510.1); Has 684 Blast hits to 681 proteins in 93 species: Archae - 0; Bacteria - 123; Metazoa - 0; Fungi - 0; Plants - 317; Viruses - 0; Other Eukaryotes - 244 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      13122082..13125328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179419.4 → NP_849750.1  cytosolic invertase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849750.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LQF2
      UniProtKB/TrEMBL
      A0A178W322, A0A5S9WJ84
      Conserved Domains (1) summary
      PLN03005
      Location:1 → 550
      PLN03005; beta-fructofuranosidase

    2. NM_103255.2 → NP_174791.2  cytosolic invertase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174791.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LQF2
      UniProtKB/TrEMBL
      A0A178W322, A0A5S9WJ84
      Conserved Domains (1) summary
      PLN03005
      Location:1 → 550
      PLN03005; beta-fructofuranosidase

    3. NM_001036066.2 → NP_001031143.1  cytosolic invertase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4HZY9
      Conserved Domains (1) summary
      cl17340
      Location:1 → 455
      Glyco_hydro_100; Alkaline and neutral invertase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LQF2.1

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