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    EER4 Transcription initiation factor TFIID subunit A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838316, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EER4
    Official Full Name
    Transcription initiation factor TFIID subunit A
    Primary source
    TAIR:AT1G17440
    Locus tag
    AT1G17440
    See related
    Araport:AT1G17440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CKH1; CYTOKININ-HYPERSENSITIVE 1; ENHANCED ETHYLENE RESPONSE 4; F1L3.13; TAF12B; TBP-ASSOCIATED FACTOR 12B
    Summary
    Encodes one of two Arabidopsis proteins with similarity to the TBP-associated factor TAF12. The gene product is an EIN3-interacting TFIID transcription factor required for proper ethylene response, including ERF1 induction. Loss of function mutants show enhanced response to ethylene. Located in nucleus and expressed throughout the plant. Required for ERF1 expression. Cytokinin-hypersensitive 1 (CKH1) mutants are characterized by rapidly growing calli with a green color at low levels of cytokinins, which are insufficient to induce such cytokinin responses in wild-type explants. It is hypothesized that CKH1 acts as a negative regulator of cytokinin signaling in Arabidopsis.
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    Genomic context

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    See EER4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (5983984..5987934, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene lipoxygenase 3 Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene B-block binding subunit of TFIIIC Neighboring gene ELF4-like 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The CKH1/EER4 gene encoding a TAF12-like protein negatively regulates cytokinin sensitivity in Arabidopsis thaliana. Kubo M, et al. Plant Cell Physiol, 2011 Apr. PMID 21357579
    2. The CKH2/PKL chromatin remodeling factor negatively regulates cytokinin responses in Arabidopsis calli. Furuta K, et al. Plant Cell Physiol, 2011 Apr. PMID 21357580
    3. Arabidopsis enhanced ethylene response 4 encodes an EIN3-interacting TFIID transcription factor required for proper ethylene response, including ERF1 induction. Robles LM, et al. J Exp Bot, 2007. PMID 17526916
    4. The Cytokinin-hypersensitive genes of Arabidopsis negatively regulate the cytokinin-signaling pathway for cell division and chloroplast development. Kubo M, et al. Plant J, 2000 Aug. PMID 10929131
    5. Three functionally redundant plant-specific paralogs are core subunits of the SAGA histone acetyltransferase complex in Arabidopsis. Wu CJ, et al. Mol Plant, 2021 Jul 5. PMID 33737195

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CKH1/EER4/AtTAF12b and CKH2/PKL may act together on cytokinin-regulated genes.
      Title: The CKH2/PKL chromatin remodeling factor negatively regulates cytokinin responses in Arabidopsis calli.
    2. CKH1 protein regulates a set of genes involved in late signaling processes governing a range of cytokinin responses, including cell proliferation and differentiation.
      Title: The CKH1/EER4 gene encoding a TAF12-like protein negatively regulates cytokinin sensitivity in Arabidopsis thaliana.
    3. EER4 is localized to the nucleus where it probably recruits EIN3 and other transcription factors for expression of a subset of genes required for either manifestation or subsequent dampening of the response to ethylene.
      Title: Arabidopsis enhanced ethylene response 4 encodes an EIN3-interacting TFIID transcription factor required for proper ethylene response, including ERF1 induction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101605.5
    NM_179349.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytokinin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of ethylene-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transcription initiation factor TFIID subunit A
    NP_564023.1
    • ENHANCED ETHYLENE RESPONSE 4 (EER4); FUNCTIONS IN: transcription initiation factor activity, DNA binding; INVOLVED IN: regulation of ethylene mediated signaling pathway, jasmonic acid mediated signaling pathway, transcription initiation; LOCATED IN: nucleus, transcription factor TFIID complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcription initiation factor TFIID (InterPro:IPR003228), Histone-fold (InterPro:IPR009072); BEST Arabidopsis thaliana protein match is: TBP-associated factor 12 (TAIR:AT3G10070.1); Has 83508 Blast hits to 36935 proteins in 1541 species: Archae - 40; Bacteria - 5554; Metazoa - 31214; Fungi - 9645; Plants - 6795; Viruses - 322; Other Eukaryotes - 29938 (source: NCBI BLink).
    NP_849680.1
    • ENHANCED ETHYLENE RESPONSE 4 (EER4); FUNCTIONS IN: DNA binding, transcription initiation factor activity; INVOLVED IN: regulation of ethylene mediated signaling pathway, jasmonic acid mediated signaling pathway, transcription initiation; LOCATED IN: nucleus, transcription factor TFIID complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcription initiation factor TFIID (InterPro:IPR003228), Histone-fold (InterPro:IPR009072); BEST Arabidopsis thaliana protein match is: TBP-associated factor 12 (TAIR:AT3G10070.1); Has 83508 Blast hits to 36935 proteins in 1541 species: Archae - 40; Bacteria - 5554; Metazoa - 31214; Fungi - 9645; Plants - 6795; Viruses - 322; Other Eukaryotes - 29938 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5983984..5987934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101605.5 → NP_564023.1  Transcription initiation factor TFIID subunit A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564023.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q940A7, Q9LQJ7
      UniProtKB/TrEMBL
      A0A5S9UWP2, A0A7G2DXG2
      Conserved Domains (2) summary
      TIGR01628
      Location:227 → 350
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd07981
      Location:528 → 593
      TAF12; TATA Binding Protein (TBP) Associated Factor 12

    2. NM_179349.1 → NP_849680.1  Transcription initiation factor TFIID subunit A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849680.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q940A7, Q9LQJ7
      UniProtKB/TrEMBL
      A0A5S9UWP2, A0A7G2DXG2
      Conserved Domains (2) summary
      TIGR01628
      Location:227 → 350
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd07981
      Location:528 → 593
      TAF12; TATA Binding Protein (TBP) Associated Factor 12
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q940A7.1

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