U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    UBC36 ubiquitin-conjugating enzyme 36 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838260, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    UBC36
    Official Full Name
    ubiquitin-conjugating enzyme 36
    Primary source
    TAIR:AT1G16890
    Locus tag
    AT1G16890
    See related
    Araport:AT1G16890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtUBC36; F17F16.19; UBC13B; UBIQUITIN CONJUGATING ENZYME 13B; ubiquitin-conjugating enzyme 36
    Summary
    UBC36/UBC13B encodes a protein that may play a role in DNA damage responses and error-free post-replicative DNA repair. It can bind to the MMZ/UEV1 proteins in vitro.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See UBC36 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (5776177..5778529, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Ubiquitin-specific protease family C19-related protein Neighboring gene mitochondrial 28S ribosomal protein S29-like protein Neighboring gene uridylyltransferase-like protein Neighboring gene ncRNA Neighboring gene Alg9-like mannosyltransferase family Neighboring gene Curculin-like (mannose-binding) lectin family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Arabidopsis UBC13 differentially regulates two programmed cell death pathways in responses to pathogen and low-temperature stress. Wang L, et al. New Phytol, 2019 Jan. PMID 30218535
    2. UBC13, an E2 enzyme for Lys63-linked ubiquitination, functions in root development by affecting auxin signaling and Aux/IAA protein stability. Wen R, et al. Plant J, 2014 Nov. PMID 25142088
    3. A lysine-63-linked ubiquitin chain-forming conjugase, UBC13, promotes the developmental responses to iron deficiency in Arabidopsis roots. Li W, et al. Plant J, 2010 Apr. PMID 20113438
    4. Arabidopsis thaliana UBC13: implication of error-free DNA damage tolerance and Lys63-linked polyubiquitylation in plants. Wen R, et al. Plant Mol Biol, 2006 May. PMID 16786304
    5. Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and is involved in DNA damage response. Wen R, et al. Plant Cell, 2008 Jan. PMID 18178771, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results revealed that UBC13 is a key regulator in plant response to low temperature and pathogens.
      Title: Arabidopsis UBC13 differentially regulates two programmed cell death pathways in responses to pathogen and low-temperature stress.
    2. UBC13 activity is critical for all major aspects of root development. The double mutant plants were insensitive to auxin treatments and the ubc13 mutant had a reduced auxin response.
      Title: UBC13, an E2 enzyme for Lys63-linked ubiquitination, functions in root development by affecting auxin signaling and Aux/IAA protein stability.
    3. Arabidopsis contains two highly conserved and likely duplicated UBC13 genes, AtUBC13A and AtUBC13B. Data suggests the existence of an error-free DNA damage tolerance pathway in plants. [UBC13B]
      Title: Arabidopsis thaliana UBC13: implication of error-free DNA damage tolerance and Lys63-linked polyubiquitylation in plants.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001198088.1
    NM_101550.4
    NM_179347.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to iron ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root epidermal cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of UBC13-MMS2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ubiquitin-conjugating enzyme 36
    NP_001185017.1
    • ubiquitin-conjugating enzyme 36 (UBC36); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 35 (TAIR:AT1G78870.2).
    NP_564011.1
    • ubiquitin-conjugating enzyme 36 (UBC36); FUNCTIONS IN: ubiquitin-protein ligase activity, protein binding; INVOLVED IN: root epidermal cell differentiation, response to iron ion, ubiquitin-dependent protein catabolic process; LOCATED IN: UBC13-MMS2 complex, plasma membrane; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 35 (TAIR:AT1G78870.2); Has 10361 Blast hits to 10354 proteins in 399 species: Archae - 0; Bacteria - 4; Metazoa - 4571; Fungi - 2197; Plants - 1880; Viruses - 23; Other Eukaryotes - 1686 (source: NCBI BLink).
    NP_849678.1
    • ubiquitin-conjugating enzyme 36 (UBC36); FUNCTIONS IN: ubiquitin-protein ligase activity, protein binding; INVOLVED IN: root epidermal cell differentiation, response to iron ion, ubiquitin-dependent protein catabolic process; LOCATED IN: UBC13-MMS2 complex, plasma membrane; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 35 (TAIR:AT1G78870.2); Has 10019 Blast hits to 10015 proteins in 393 species: Archae - 0; Bacteria - 4; Metazoa - 4493; Fungi - 2117; Plants - 1786; Viruses - 23; Other Eukaryotes - 1596 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5776177..5778529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198088.1 → NP_001185017.1  ubiquitin-conjugating enzyme 36 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I615
      Conserved Domains (2) summary
      COG5078
      Location:1 → 160
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cl00154
      Location:6 → 159
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_101550.4 → NP_564011.1  ubiquitin-conjugating enzyme 36 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564011.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EDA7, Q9FZ48
      UniProtKB/TrEMBL
      A0A5S9URX4, A0A654ECH4
      Conserved Domains (1) summary
      cl00154
      Location:6 → 150
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_179347.2 → NP_849678.1  ubiquitin-conjugating enzyme 36 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849678.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FZ48
      Conserved Domains (1) summary
      cl00154
      Location:2 → 117
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FZ48.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.