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    PAI1 phosphoribosylanthranilate isomerase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837292, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAI1
    Official Full Name
    phosphoribosylanthranilate isomerase 1
    Primary source
    TAIR:AT1G07780
    Locus tag
    AT1G07780
    See related
    Araport:AT1G07780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F24B9.11; F24B9_11; PHOSPHORIBOSYLANTHRANILATE ISOMERASE; phosphoribosylanthranilate isomerase 1; TRANSIENT RECEPTOR POTENTIAL 6; TRP6
    Summary
    Encodes phosphoribosylanthranilate isomerase which catalyzes the third step of the tryptophan biosynthetic pathway. Member of gene family.
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    Genomic context

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    See PAI1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (2409865..2412777, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene tRNA-His Neighboring gene ribosomal protein S15A Neighboring gene Histone superfamily protein Neighboring gene forkhead box protein G1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epigenetic control of an endogenous gene family is revealed by a novel blue fluorescent mutant of Arabidopsis. Bender J, et al. Cell, 1995 Dec 1. PMID 8521489
    2. Arabidopsis phosphoribosylanthranilate isomerase: molecular genetic analysis of triplicate tryptophan pathway genes. Li J, et al. Plant Cell, 1995 Apr. PMID 7773017, Free PMC Article
    3. Immunological characterization and chloroplast localization of the tryptophan biosynthetic enzymes of the flowering plant Arabidopsis thaliana. Zhao J, et al. J Biol Chem, 1995 Mar 17. PMID 7890741
    4. The Arabidopsis metacaspase9 degradome. Tsiatsiani L, et al. Plant Cell, 2013 Aug. PMID 23964026, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001123771.1
    NM_001198002.2
    NM_001331729.1
    NM_001331730.1
    NM_001331731.1
    NM_001331732.1
    NM_001331733.1
    NM_001331734.1
    NM_001331735.1
    NM_001331736.1
    NM_100652.5
    NM_179275.4
    NM_202055.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphoribosylanthranilate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylanthranilate isomerase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables phosphoribosylanthranilate isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tryptophan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tryptophan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tryptophan biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    phosphoribosylanthranilate isomerase 1
    NP_001117243.1
    • phosphoribosylanthranilate isomerase 1 (PAI1); CONTAINS InterPro DOMAIN/s: N-(5'phosphoribosyl)anthranilate isomerase (PRAI) (InterPro:IPR001240), Aldolase-type TIM barrel (InterPro:IPR013785), Ribulose-phosphate binding barrel (InterPro:IPR011060); BEST Arabidopsis thaliana protein match is: phosphoribosylanthranilate isomerase 2 (TAIR:AT5G05590.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_001184931.1
    • phosphoribosylanthranilate isomerase 1 (PAI1); CONTAINS InterPro DOMAIN/s: N-(5'phosphoribosyl)anthranilate isomerase (PRAI) (InterPro:IPR001240), Aldolase-type TIM barrel (InterPro:IPR013785), Ribulose-phosphate binding barrel (InterPro:IPR011060); BEST Arabidopsis thaliana protein match is: phosphoribosylanthranilate isomerase 2 (TAIR:AT5G05590.1).
    NP_172257.1
    • phosphoribosylanthranilate isomerase 1 (PAI1); CONTAINS InterPro DOMAIN/s: N-(5'phosphoribosyl)anthranilate isomerase (PRAI) (InterPro:IPR001240), Aldolase-type TIM barrel (InterPro:IPR013785), Ribulose-phosphate binding barrel (InterPro:IPR011060); BEST Arabidopsis thaliana protein match is: phosphoribosylanthranilate isomerase 2 (TAIR:AT5G05590.1); Has 5472 Blast hits to 5471 proteins in 2119 species: Archae - 168; Bacteria - 3853; Metazoa - 4; Fungi - 235; Plants - 77; Viruses - 0; Other Eukaryotes - 1135 (source: NCBI BLink).
    NP_849606.1
    • phosphoribosylanthranilate isomerase 1 (PAI1); CONTAINS InterPro DOMAIN/s: N-(5'phosphoribosyl)anthranilate isomerase (PRAI) (InterPro:IPR001240), Aldolase-type TIM barrel (InterPro:IPR013785), Ribulose-phosphate binding barrel (InterPro:IPR011060); BEST Arabidopsis thaliana protein match is: phosphoribosylanthranilate isomerase 2 (TAIR:AT5G05590.1); Has 5472 Blast hits to 5471 proteins in 2119 species: Archae - 168; Bacteria - 3853; Metazoa - 4; Fungi - 235; Plants - 77; Viruses - 0; Other Eukaryotes - 1135 (source: NCBI BLink).
    NP_973784.2
    • phosphoribosylanthranilate isomerase 1 (PAI1); CONTAINS InterPro DOMAIN/s: N-(5'phosphoribosyl)anthranilate isomerase (PRAI) (InterPro:IPR001240), Aldolase-type TIM barrel (InterPro:IPR013785), Ribulose-phosphate binding barrel (InterPro:IPR011060); BEST Arabidopsis thaliana protein match is: phosphoribosylanthranilate isomerase 2 (TAIR:AT5G05590.1); Has 5472 Blast hits to 5471 proteins in 2119 species: Archae - 168; Bacteria - 3853; Metazoa - 4; Fungi - 235; Plants - 77; Viruses - 0; Other Eukaryotes - 1135 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2409865..2412777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198002.2 → NP_001184931.1  phosphoribosylanthranilate isomerase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184931.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EDG7, Q42440, Q7G9J9
      UniProtKB/TrEMBL
      A0A178WLS8, A0A5S9Y1Y1, A0A7G2F7D8
      Conserved Domains (1) summary
      PLN02363
      Location:19 → 275
      PLN02363; phosphoribosylanthranilate isomerase

    2. NM_179275.4 → NP_849606.1  phosphoribosylanthranilate isomerase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849606.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EDG7, Q42440, Q7G9J9
      UniProtKB/TrEMBL
      A0A178WLS8, A0A5S9Y1Y1, A0A7G2F7D8
      Conserved Domains (1) summary
      PLN02363
      Location:19 → 275
      PLN02363; phosphoribosylanthranilate isomerase

    3. NM_100652.5 → NP_172257.1  phosphoribosylanthranilate isomerase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172257.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EDG7, Q42440, Q7G9J9
      UniProtKB/TrEMBL
      A0A178WLS8, A0A5S9Y1Y1, A0A7G2F7D8
      Conserved Domains (1) summary
      PLN02363
      Location:19 → 275
      PLN02363; phosphoribosylanthranilate isomerase

    4. NM_202055.4 → NP_973784.2  phosphoribosylanthranilate isomerase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973784.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EDG7, Q42440, Q7G9J9
      UniProtKB/TrEMBL
      A0A178WLS8, A0A5S9Y1Y1, A0A7G2F7D8
      Conserved Domains (1) summary
      PLN02363
      Location:19 → 275
      PLN02363; phosphoribosylanthranilate isomerase

    5. NM_001331733.1 → NP_001322380.1  phosphoribosylanthranilate isomerase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ATU6
      Conserved Domains (1) summary
      PLN02363
      Location:19 → 212
      PLN02363; phosphoribosylanthranilate isomerase

    6. NM_001331734.1 → NP_001322381.1  phosphoribosylanthranilate isomerase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ATT5

    7. NM_001331729.1 → NP_001322384.1  phosphoribosylanthranilate isomerase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EDG7, Q42440, Q7G9J9
      UniProtKB/TrEMBL
      A0A178WLS8, A0A5S9Y1Y1, A0A7G2F7D8
      Conserved Domains (1) summary
      PLN02363
      Location:19 → 275
      PLN02363; phosphoribosylanthranilate isomerase

    8. NM_001331736.1 → NP_001322383.1  phosphoribosylanthranilate isomerase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EDG7, Q42440, Q7G9J9
      UniProtKB/TrEMBL
      A0A178WLS8, A0A5S9Y1Y1, A0A7G2F7D8
      Conserved Domains (1) summary
      PLN02363
      Location:19 → 275
      PLN02363; phosphoribosylanthranilate isomerase

    9. NM_001331735.1 → NP_001322382.1  phosphoribosylanthranilate isomerase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ATU6
      Conserved Domains (1) summary
      PLN02363
      Location:19 → 212
      PLN02363; phosphoribosylanthranilate isomerase

    10. NM_001331732.1 → NP_001322387.1  phosphoribosylanthranilate isomerase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EDG7, Q42440, Q7G9J9
      UniProtKB/TrEMBL
      A0A178WLS8, A0A5S9Y1Y1, A0A7G2F7D8
      Conserved Domains (1) summary
      PLN02363
      Location:19 → 275
      PLN02363; phosphoribosylanthranilate isomerase

    11. NM_001331731.1 → NP_001322386.1  phosphoribosylanthranilate isomerase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EDG7, Q42440, Q7G9J9
      UniProtKB/TrEMBL
      A0A178WLS8, A0A5S9Y1Y1, A0A7G2F7D8
      Conserved Domains (1) summary
      PLN02363
      Location:19 → 275
      PLN02363; phosphoribosylanthranilate isomerase

    12. NM_001331730.1 → NP_001322385.1  phosphoribosylanthranilate isomerase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3H4J9

    13. NM_001123771.1 → NP_001117243.1  phosphoribosylanthranilate isomerase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001117243.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3H4J9
      Conserved Domains (2) summary
      PLN02363
      Location:19 → 207
      PLN02363; phosphoribosylanthranilate isomerase
      cd00405
      Location:68 → 210
      PRAI; Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42440.1

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