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    THAS1 thalianol synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834852, updated on 18-Sep-2024

    Summary

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    Official Symbol
    THAS1
    Official Full Name
    thalianol synthase 1
    Primary source
    TAIR:AT5G48010
    Locus tag
    AT5G48010
    See related
    Araport:AT5G48010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana thalianol synthase 1; AtTHAS1; MDN11.9; MDN11_9; THALIANOL SYNTHASE; thalianol synthase 1; THAS
    Summary
    Encodes an oxidosqualene cyclase involved in the biosynthesis of thalianol, a tricyclic triterpenoid of unknown function. Overexpression of THAS leads to dwarfing in the aerial tissues of Arabidopsis plants, but increases their root length. THAS is part of a small operon-like cluster of genes (with At5g48000 (THAH) and At5g47990 (THAD)) involved in thalianol metabolism.
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    Genomic context

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    See THAS1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Sequence:
    Chromosome: 5; NC_003076.8 (19456837..19461706)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 5 Neighboring gene cytochrome P450, family 708, subfamily A, polypeptide 2 Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene gametophytic factor 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome mining to identify new plant triterpenoids. Fazio GC, et al. J Am Chem Soc, 2004 May 12. PMID 15125655
    2. Arabidopsis thaliana calcium-dependent lipid-binding protein (AtCLB): a novel repressor of abiotic stress response. de Silva K, et al. J Exp Bot, 2011 May. PMID 21252258
    3. Metabolic diversification--independent assembly of operon-like gene clusters in different plants. Field B, et al. Science, 2008 Apr 25. PMID 18356490
    4. Formation of plant metabolic gene clusters within dynamic chromosomal regions. Field B, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21876149, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    NM_001085264.2
    NM_124175.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables thalianol synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to gravity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thalianol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tricyclic triterpenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    thalianol synthase 1
    NP_001078733.1
    • thalianol synthase 1 (THAS1); CONTAINS InterPro DOMAIN/s: Terpene synthase, conserved site (InterPro:IPR002365), Squalene cyclase (InterPro:IPR018333), Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: baruol synthase 1 (TAIR:AT4G15370.1); Has 1966 Blast hits to 1917 proteins in 564 species: Archae - 4; Bacteria - 840; Metazoa - 80; Fungi - 239; Plants - 603; Viruses - 0; Other Eukaryotes - 200 (source: NCBI BLink).
    NP_199612.3
    • thalianol synthase 1 (THAS1); CONTAINS InterPro DOMAIN/s: Terpene synthase, conserved site (InterPro:IPR002365), Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Squalene cyclase (InterPro:IPR018333), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: baruol synthase 1 (TAIR:AT4G15370.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19456837..19461706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001085264.2 → NP_001078733.1  thalianol synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078733.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WSZ0, Q7XJ43, Q9FI37
      UniProtKB/TrEMBL
      A0A178UPI8, A0A7G2FF69
      Conserved Domains (3) summary
      PLN03012
      Location:1 → 766
      PLN03012; Camelliol C synthase
      cd02892
      Location:99 → 757
      SQCY_1; Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization ...
      pfam09279
      Location:42 → 115
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    2. NM_124175.4 → NP_199612.3  thalianol synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199612.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UPI8, A0A7G2FF69
      Conserved Domains (3) summary
      PLN03012
      Location:1 → 758
      PLN03012; Camelliol C synthase
      cd02892
      Location:99 → 749
      SQCY_1; Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization ...
      pfam09279
      Location:42 → 115
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FI37.2

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