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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001302272.2 → NP_001289201.1 thioredoxin-dependent peroxide reductase, mitochondrial isoform c precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
- Source sequence(s)
-
BC008435, BG282768, BX382389, HY173455
- UniProtKB/Swiss-Prot
-
P30048
- Conserved Domains (2) summary
-
- COG0450
Location:65 → 186
- AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
- cd03015
Location:65 → 186
- PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
-
NM_006793.5 → NP_006784.1 thioredoxin-dependent peroxide reductase, mitochondrial isoform a precursor
See identical proteins and their annotated locations for NP_006784.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
- Source sequence(s)
-
BC007062, BC008435, CD687044
- Consensus CDS
-
CCDS7611.1
- UniProtKB/Swiss-Prot
- B2R7Z0, D3DRC9, E9PH29, P30048, P35690, Q0D2H1, Q13776, Q5T5V2, Q96HK4
- UniProtKB/TrEMBL
- A0A384MTR2, Q53HC2
- Related
- ENSP00000298510.2, ENST00000298510.4
- Conserved Domains (1) summary
-
- cd03015
Location:65 → 236
- PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
RNA
-
NR_126102.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AV761690, BC008435, CD687044, HY173455
-
NR_126103.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) lacks two alternate exons in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
BC008435, BG115645, CD687044, HY173455
-
NR_126105.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) uses two alternate splice sites and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
BC008435, BF209381, CD687044, HY173455
-
NR_126106.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) uses two alternate splice sites and lacks three internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
BC008435, HY082255
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000010.11 Reference GRCh38.p14 Primary Assembly
- Range
-
119167720..119178812 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060934.1 Alternate T2T-CHM13v2.0
- Range
-
120063136..120074228 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_014098.3: Suppressed sequence
- Description
- NM_014098.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript contains unsupported non-consensus splice sites.