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    kinase family with ARM repeat domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831988, updated on 18-Sep-2024

    Summary

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    Official Full Name
    kinase family with ARM repeat domain-containing protein
    Primary source
    TAIR:AT5G18700
    Locus tag
    AT5G18700
    See related
    Araport:AT5G18700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EMB3013; EMBRYO DEFECTIVE 3013; RUK; RUNKEL; T1A4.80; T1A4_80
    Summary
    Encodes a microtubule-associated kinase-like protein RUNKEL (RUK). Contains a putative serine/threonine kinase domain and a microtubule-binding domain. RUK directly binds to microtubules in vitro and colocalizes with mitotic preprophase band, spindle, and phragmoplast in vivo. Required for cell plate expansion in cytokinesis.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (6235032..6240916, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene beta-amylase 3 Neighboring gene tubby like protein 11 Neighboring gene arabinogalactan protein 25 Neighboring gene uncharacterized protein Neighboring gene DNAJ heat shock amino-terminal domain protein, putative (DUF3444) Neighboring gene DNAJ heat shock amino-terminal domain protein, putative (DUF3444)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microtubule-associated kinase-like protein RUNKEL needed [corrected] for cell plate expansion in Arabidopsis cytokinesis. Krupnova T, et al. Curr Biol, 2009 Mar 24. PMID 19268593
    2. Cellularisation in the endosperm of Arabidopsis thaliana is coupled to mitosis and shares multiple components with cytokinesis. Sørensen MB, et al. Development, 2002 Dec. PMID 12421698
    3. Genetic dissection of cytokinesis. Nacry P, et al. Plant Mol Biol, 2000 Aug. PMID 11089872
    4. The microtubule-associated kinase-like protein RUNKEL functions in somatic and syncytial cytokinesis. Krupnova T, et al. Plant J, 2013 Jun. PMID 23451828
    5. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate a role for RUNKEL (RUK) in both phragmoplast-based cytokinesis in somatic cells and syncytial cytokinesis in reproductive cells.
      Title: The microtubule-associated kinase-like protein RUNKEL functions in somatic and syncytial cytokinesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121875.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinesis by cell plate formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within endosperm cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosperm cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microsporogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phragmoplast assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in radial microtubular system formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phragmoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 
    located_in preprophase band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinase family with ARM repeat domain-containing protein
    NP_197371.2
    • Protein kinase family protein with ARM repeat domain; CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase domain (InterPro:IPR002290), Armadillo-like helical (InterPro:IPR011989), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT1G33940.2); Has 133671 Blast hits to 131461 proteins in 4761 species: Archae - 230; Bacteria - 15366; Metazoa - 49337; Fungi - 13216; Plants - 32681; Viruses - 728; Other Eukaryotes - 22113 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6235032..6240916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121875.4 → NP_197371.2  kinase family with ARM repeat domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197371.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JY37
      UniProtKB/TrEMBL
      A0A178UQV6, A0A5S9Y5B7, A0A654G2D7
      Conserved Domains (1) summary
      cd14010
      Location:3 → 253
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JY37.1

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