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    ZMAT3 zinc finger matrin-type 3 [ Homo sapiens (human) ]

    Gene ID: 64393, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZMAT3provided by HGNC
    Official Full Name
    zinc finger matrin-type 3provided by HGNC
    Primary source
    HGNC:HGNC:29983
    See related
    Ensembl:ENSG00000172667 MIM:606452; AllianceGenome:HGNC:29983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WIG1; WIG-1; PAG608
    Summary
    This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 11.2), gall bladder (RPKM 5.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZMAT3 in Genome Data Viewer
    Location:
    3q26.32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (179017223..179072513, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (181821051..181876314, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (178735011..178790301, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene KCNMB2 antisense RNA 1 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 2 Neighboring gene uncharacterized LOC124909461 Neighboring gene NANOG hESC enhancer GRCh37_chr3:178545086-178545618 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:178578153-178578979 Neighboring gene uncharacterized LOC124906307 Neighboring gene MPRA-validated peak4949 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20859 Neighboring gene PIK3CA divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20861 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:178866509-178867008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14912 Neighboring gene small nucleolar RNA SNORA25 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The alphaherpesvirus US3/ORF66 protein kinases direct phosphorylation of the nuclear matrix protein matrin 3. Erazo A, et al. J Virol, 2011 Jan. PMID 20962082, Free PMC Article
    2. The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma. Muys BR, et al. Genes Dev, 2021 Jan 1. PMID 33334821, Free PMC Article
    3. Preparation of a novel monoclonal antibody specific for WIG-1 and detection of its expression pattern in human esophageal carcinoma. Zou YB, et al. Hybridoma (Larchmt), 2010 Oct. PMID 21050045
    4. Zinc induces cell cycle arrest and apoptosis by upregulation of WIG-1 in esophageal squamous cancer cell line EC109. Guo W, et al. Tumour Biol, 2011 Aug. PMID 21559779
    5. Cloning and chromosomal localization of human WIG-1/PAG608 and demonstration of amplification with increased expression in primary squamous cell carcinoma of the lung. Varmeh-Ziaie S, et al. Cancer Lett, 2001 Dec 28. PMID 11689294

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1.
      Title: eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1.
    2. The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma.
      Title: The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma.
    3. Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.
      Title: Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.
    4. WIG1 governs the miRNA-dependent and the miRNA-independent recruitment of AGO2 to lower the stability of and suppress the translation of ACOT7 mRNA.
      Title: WIG1 is crucial for AGO2-mediated ACOT7 mRNA silencing via miRNA-dependent and -independent mechanisms.
    5. we propose that Wig1, a key p53 downstream molecule in HD condition, play an important role in stabilizing mutant Htt mRNA and thereby accelerating HD pathology in the mHtt-p53-Wig1 positive feedback manner
      Title: Allele-specific regulation of mutant Huntingtin by Wig1, a downstream target of p53.
    6. expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma
      Title: Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma.
    7. Results suggest a role of Wig-1 as a survival factor that directs the p53 stress response toward cell cycle arrest rather than apoptosis through the regulation of FAS and 14-3-3sigma mRNA levels.
      Title: Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3σ.
    8. PSF and MATR3 are cellular host factors that bind viral RNA and promote Rev activity.
      Title: HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3.
    9. The data indicated a novel role for Wig1 in RNA-induced silencing complex target accessibility, which is a key step in RNA-mediated gene silencing. Fine tuning of p21 levels by Wig1 was essential for the prevention of cellular senescence.
      Title: Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment.
    10. Wig-1 knockdown causes a dramatic inhibition of N-Myc expression and triggers differentiation in neuroblastoma cells carrying amplified N-Myc.
      Title: Wig-1, a novel regulator of N-Myc mRNA and N-Myc-driven tumor growth.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12296, FLJ31683, MGC10613

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger matrin-type protein 3
    Names
    WIG-1/PAG608 protein
    p53 target zinc finger protein
    p53-activated gene 608 protein
    zinc finger protein WIG1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050678.1 RefSeqGene

      Range
      5471..60057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001375824.1 → NP_001362753.1  zinc finger matrin-type protein 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC117456
      Consensus CDS
      CCDS3224.1
      UniProtKB/Swiss-Prot
      B3KVA6, D3DNR1, Q96A21, Q9HA38
      Conserved Domains (2) summary
      smart00451
      Location:67 → 101
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:72 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001375825.1 → NP_001362754.1  zinc finger matrin-type protein 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC117456
      Consensus CDS
      CCDS3224.1
      UniProtKB/Swiss-Prot
      B3KVA6, D3DNR1, Q96A21, Q9HA38
      Conserved Domains (2) summary
      smart00451
      Location:67 → 101
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:72 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001375826.1 → NP_001362755.1  zinc finger matrin-type protein 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC117456
      Consensus CDS
      CCDS46962.1
      Conserved Domains (2) summary
      smart00451
      Location:67 → 101
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:72 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001375827.1 → NP_001362756.1  zinc finger matrin-type protein 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC117456
      Consensus CDS
      CCDS46962.1
      Conserved Domains (2) summary
      smart00451
      Location:67 → 101
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:72 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001375828.1 → NP_001362757.1  zinc finger matrin-type protein 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC117456
      Consensus CDS
      CCDS46962.1
      Conserved Domains (2) summary
      smart00451
      Location:67 → 101
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:72 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001375829.1 → NP_001362758.1  zinc finger matrin-type protein 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC117456
      Consensus CDS
      CCDS46962.1
      Conserved Domains (2) summary
      smart00451
      Location:67 → 101
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:72 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_022470.4 → NP_071915.1  zinc finger matrin-type protein 3 isoform 1

      See identical proteins and their annotated locations for NP_071915.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate exon in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (1) includes one extra residue in the C-terminal region, compared to isoform 2.
      Source sequence(s)
      AC117456, BC002896, DA001239
      Consensus CDS
      CCDS3224.1
      UniProtKB/Swiss-Prot
      B3KVA6, D3DNR1, Q96A21, Q9HA38
      Related
      ENSP00000311221.2, ENST00000311417.7
      Conserved Domains (2) summary
      smart00451
      Location:67 → 101
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:72 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_152240.3 → NP_689426.1  zinc finger matrin-type protein 3 isoform 2

      See identical proteins and their annotated locations for NP_689426.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the shorter isoform (2).
      Source sequence(s)
      AC117456, AK122768, BC002896, DA001239
      Consensus CDS
      CCDS46962.1
      UniProtKB/Swiss-Prot
      Q9HA38
      Related
      ENSP00000396506.1, ENST00000432729.5
      Conserved Domains (2) summary
      smart00451
      Location:67 → 101
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:72 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_164720.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC117456

    2. NR_164721.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC117456

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      179017223..179072513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513073.3 → XP_011511375.1  zinc finger matrin-type protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011511375.1

      UniProtKB/Swiss-Prot
      B3KVA6, D3DNR1, Q96A21, Q9HA38
      Conserved Domains (2) summary
      smart00451
      Location:67 → 101
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:72 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      181821051..181876314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347542.1 → XP_054203517.1  zinc finger matrin-type protein 3 isoform X1

      UniProtKB/Swiss-Prot
      B3KVA6, D3DNR1, Q96A21, Q9HA38
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HA38.1 GenPept UniProtKB/Swiss-Prot:Q9HA38

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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